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    RPS2 NB-ARC domain-containing disease resistance protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828715, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RPS2
    Official Full Name
    NB-ARC domain-containing disease resistance protein
    Primary source
    TAIR:AT4G26090
    Locus tag
    AT4G26090
    See related
    Araport:AT4G26090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DISEASE RESISTANCE PROTEIN RPS2; F20B18.200; F20B18_200; RESISTANT TO P. SYRINGAE 2
    Summary
    Encodes a plasma membrane protein with leucine-rich repeat, leucine zipper, and P loop domains that confers resistance to Pseudomonas syringae infection by interacting with the avirulence gene avrRpt2. RPS2 protein interacts directly with plasma membrane associated protein RIN4 and this interaction is disrupted by avrRpt2.
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    Genomic context

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    See RPS2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    1
    Sequence:
    Chromosome: 4; NC_003075.7 (13224338..13227872)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Ribosomal protein L18ae family Neighboring gene MAP kinase/ ERK kinase 1 Neighboring gene Protein phosphatase 2C family protein Neighboring gene ncRNA Neighboring gene casein kinase 1 Neighboring gene nucleosome assembly protein1;1 Neighboring gene Ankyrin repeat family protein / BTB/POZ domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutational analysis of the Arabidopsis RPS2 disease resistance gene and the corresponding pseudomonas syringae avrRpt2 avirulence gene. Axtell MJ, et al. Mol Plant Microbe Interact, 2001 Feb. PMID 11204781
    2. The leucine-rich repeat domain can determine effective interaction between RPS2 and other host factors in arabidopsis RPS2-mediated disease resistance. Banerjee D, et al. Genetics, 2001 May. PMID 11333251, Free PMC Article
    3. Development of a virus-induced gene-silencing system for functional analysis of the RPS2-dependent resistance signalling pathways in Arabidopsis. Cai XZ, et al. Plant Mol Biol, 2006 Sep. PMID 16845481
    4. AvrRpm1 missense mutations weakly activate RPS2-mediated immune response in Arabidopsis thaliana. Cherkis KA, et al. PLoS One, 2012. PMID 22880057, Free PMC Article
    5. Genetic architecture and pleiotropy shape costs of Rps2-mediated resistance in Arabidopsis thaliana. MacQueen A, et al. Nat Plants, 2016 Jul 18. PMID 27428524, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Homeostasis of Arabidopsis R protein RPS2 is negatively regulated by the RING-type E3 ligase MUSE16.
      Title: Homeostasis of Arabidopsis R protein RPS2 is negatively regulated by the RING-type E3 ligase MUSE16.
    2. Translational Regulation of Metabolic Dynamics during Effector-Triggered Immunity.
      Title: Translational Regulation of Metabolic Dynamics during Effector-Triggered Immunity.
    3. Rps2 segregates for two expressed clades of alleles, one resistant and one susceptible. Plants with resistant Rps2 are not less fit than those with a susceptible Rps2 allele in the absence of disease. Instead, all alleles provide a fitness benefit relative to an artificial deletion because of the role of RPS2 as a negative regulator of defence.
      Title: Genetic architecture and pleiotropy shape costs of Rps2-mediated resistance in Arabidopsis thaliana.
    4. Our results indicate that AtMBD6 is involved in RNA-mediated gene silencing and it binds to RNA binding proteins like AtRPS2C, AtAGO4 and AtNTF2. AtMBD6 also interacts with histone deacetylase AtHDA6 that might have a role in chromatin condensation at the targets of RdDM
      Title: AtMBD6, a methyl CpG binding domain protein, maintains gene silencing in Arabidopsis by interacting with RNA binding proteins.
    5. MUSE13 and MUSE14 contribute to the turnover of nucleotide-binding domain and leucine-rich repeat-containing (NLR) immune receptors SNC1 and RPS2.
      Title: Plant TRAF Proteins Regulate NLR Immune Receptor Turnover.
    6. Site-directed mutagenesis in the putative catalytic triad of AvrRpm1 results in loss of both AvrRpm1-dependent virulence and AvrRpm1-mediated activation of RPM1 but causes the ability to activate the RPS2 nucleotide binding leucine-rich repeat sensor.
      Title: AvrRpm1 missense mutations weakly activate RPS2-mediated immune response in Arabidopsis thaliana.
    7. Tobacco rattle virus based virus-induce gene silencing which require RPS2-mediated resistance.
      Title: Development of a virus-induced gene-silencing system for functional analysis of the RPS2-dependent resistance signalling pathways in Arabidopsis.
    8. Two closely related RPM1-interacting proteins, RIN2 and RIN3, are characterized in A. thaliana.
      Title: A duplicated pair of Arabidopsis RING-finger E3 ligases contribute to the RPM1- and RPS2-mediated hypersensitive response.
    9. The fitness costs of disease resistance in A. thaliana plants homozygous for RPS2 or RPP5 are reported.
      Title: A novel cost of R gene resistance in the presence of disease.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    NM_118742.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within detection of bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type hypersensitive response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NB-ARC domain-containing disease resistance protein
    NP_194339.1
    • RESISTANT TO P. SYRINGAE 2 (RPS2); CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), NB-ARC (InterPro:IPR002182), Leucine-rich repeat (InterPro:IPR001611), Disease resistance protein (InterPro:IPR000767); BEST Arabidopsis thaliana protein match is: RPS5-like 1 (TAIR:AT1G12210.1); Has 21906 Blast hits to 18242 proteins in 683 species: Archae - 18; Bacteria - 1169; Metazoa - 4701; Fungi - 258; Plants - 15223; Viruses - 0; Other Eukaryotes - 537 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      13224338..13227872
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118742.2 → NP_194339.1  NB-ARC domain-containing disease resistance protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194339.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82096, Q42484, Q8L3R0, Q8L3W3, Q8L4X9, Q8L4Y0, Q8L587, Q8L5B3, Q8LKZ8, Q8LKZ9, Q8LL00, Q8LL01, Q9ASP5
      UniProtKB/TrEMBL
      A0A5S9XVY2, A0A654FSW4
      Conserved Domains (4) summary
      COG4886
      Location:520 → 775
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:535 → 559
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:680 → 704
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00931
      Location:158 → 398
      NB-ARC; NB-ARC domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q42484.1

    Gene LinkOut

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