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    APM1 aminopeptidase M1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829446, updated on 18-Sep-2024

    Summary

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    Official Symbol
    APM1
    Official Full Name
    aminopeptidase M1
    Primary source
    TAIR:AT4G33090
    Locus tag
    AT4G33090
    See related
    Araport:AT4G33090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    aminopeptidase M1; AMINOPEPTIDASE M1; ATAPM1; F4I10.20; F4I10_20
    Summary
    encodes an aminopeptidase, a ortholog of mouse microsomal AP (EC 3.4.11.2).
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    Genomic context

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    See APM1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    18
    Sequence:
    Chromosome: 4; NC_003075.7 (15965593..15970557, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene AGC (cAMP-dependent, cGMP-dependent and protein kinase C) kinase family protein Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene protein phosphatase Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cytoplasm localization of aminopeptidase M1 and its functional activity in root hair cells and BY-2 cells. Lee OR, et al. Mol Biol Rep, 2012 Dec. PMID 23065197
    2. The catalytic and protein-protein interaction domains are required for APM1 function. Hosein FN, et al. Plant Physiol, 2010 Apr. PMID 20154099, Free PMC Article
    3. Mutation of the membrane-associated M1 protease APM1 results in distinct embryonic and seedling developmental defects in Arabidopsis. Peer WA, et al. Plant Cell, 2009 Jun. PMID 19531600, Free PMC Article
    4. Identification, purification, and molecular cloning of N-1-naphthylphthalmic acid-binding plasma membrane-associated aminopeptidases from Arabidopsis. Murphy AS, et al. Plant Physiol, 2002 Mar. PMID 11891249, Free PMC Article
    5. A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Marmagne A, et al. Mol Cell Proteomics, 2007 Nov. PMID 17644812

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. APM1 localized to the cytoplasm, and its over-expression in the root hair cell caused longer root hair phenotypes.
      Title: Cytoplasm localization of aminopeptidase M1 and its functional activity in root hair cells and BY-2 cells.
    2. results suggest that both the catalytic and interaction domains are necessary for APM1 function but that APM1 function and dimerization do not require these domains to be present in the same linear molecule
      Title: The catalytic and protein-protein interaction domains are required for APM1 function.
    3. APM1 is associated with embryonic and seedling development.
      Title: Mutation of the membrane-associated M1 protease APM1 results in distinct embryonic and seedling developmental defects in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_119463.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables N-1-naphthylphthalamic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within auxin polar transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aminopeptidase M1
    NP_195035.2
    • aminopeptidase M1 (APM1); FUNCTIONS IN: aminopeptidase activity; INVOLVED IN: auxin polar transport; LOCATED IN: plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase M1, puromycin-sensitive aminopeptidase (InterPro:IPR015568), Peptidase M1, membrane alanine aminopeptidase (InterPro:IPR001930), Peptidase M1, membrane alanine aminopeptidase, N-terminal (InterPro:IPR014782); BEST Arabidopsis thaliana protein match is: Peptidase M1 family protein (TAIR:AT1G63770.3); Has 9205 Blast hits to 9101 proteins in 1870 species: Archae - 122; Bacteria - 4443; Metazoa - 2260; Fungi - 495; Plants - 237; Viruses - 0; Other Eukaryotes - 1648 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      15965593..15970557 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119463.5 → NP_195035.2  aminopeptidase M1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195035.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56WG9, Q8VZH2, Q9SN00
      UniProtKB/TrEMBL
      A0A178UWR6, A0A5S9XYV1, A0A7G2F4F1
      Conserved Domains (2) summary
      cd09601
      Location:18 → 453
      M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
      pfam11838
      Location:536 → 855
      ERAP1_C; ERAP1-like C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VZH2.1

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