COW1 Sec14p-like phosphatidylinositol transfer family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: COW1
Official Full Name: Sec14p-like phosphatidylinositol transfer family protein
Primary source: TAIR:AT4G34580
Locus tag: AT4G34580
See related: Araport:AT4G34580
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtSFH1; CAN OF WORMS1; SHORT ROOT HAIR 1; SRH1; T4L20.160; T4L20_160
Summary: Encodes COW1 (can of worms1), a phosphatidylinositol transfer protein essential for root hair tip growth. The N-terminus of the COW1 protein is 32% identical to an essential phosphatidylinositol transfer protein (PITP), the yeast Sec14 protein (sec14p) while the C-terminus is 34.5% identical to a late nodulin of Lotus japonicus, Nlj16. Expression of COW1 complements the growth defect associated with Sec14p dysfunction in yeast. GFP fused to the COW1 protein specifically accumulates at the site of root hair outgrowth.
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Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

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NM_119624.3

Function	Evidence Code	Pubs
enables phosphatidylinositol transfer activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell tip growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within root epidermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within root hair cell tip growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in root hair cell tip growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in root hair elongation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in root hair tip	IDA Inferred from Direct Assay more info	PubMed

NP_195184.2

CAN OF WORMS1 (COW1); FUNCTIONS IN: transporter activity, phosphatidylinositol transporter activity; INVOLVED IN: root epidermal cell differentiation, transport, root hair cell tip growth, cell tip growth; LOCATED IN: intracellular; EXPRESSED IN: 9 plant structures; CONTAINS InterPro DOMAIN/s: Cellular retinaldehyde-binding/triple function, C-terminal (InterPro:IPR001251), Cellular retinaldehyde-binding/triple function, N-terminal (InterPro:IPR008273), Cellular retinaldehyde binding/alpha-tocopherol transport (InterPro:IPR001071), Phosphatidylinositol transfer protein-like, N-terminal (InterPro:IPR011074); BEST Arabidopsis thaliana protein match is: Sec14p-like phosphatidylinositol transfer family protein (TAIR:AT2G16380.1); Has 3006 Blast hits to 2988 proteins in 244 species: Archae - 0; Bacteria - 0; Metazoa - 982; Fungi - 671; Plants - 907; Viruses - 0; Other Eukaryotes - 446 (source: NCBI BLink).

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