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    HDR 4-hydroxy-3-methylbut-2-enyl diphosphate reductase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829585, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HDR
    Official Full Name
    4-hydroxy-3-methylbut-2-enyl diphosphate reductase
    Primary source
    TAIR:AT4G34350
    Locus tag
    AT4G34350
    See related
    Araport:AT4G34350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    4-hydroxy-3-methylbut-2-enyl diphosphate reductase; CHLOROPLAST BIOGENESIS 6; CLB6; F10M10.120; F10M10_120; ISPH
    Summary
    Arabidopsis ISPH is involved in the plastid nonmevalonate pathway of isoprenoid biosynthesis. It was shown to complement the lethal phenotype of E. coli ispH mutant and is therefore most likely encodes a protein with 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity involved in the last step of mevalonate-independent isopentenyl biosynthesis. Mutant has Albino seedling.
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    Genomic context

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    See HDR in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Sequence:
    Chromosome: 4; NC_003075.7 (16428407..16431144, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein, putative (DUF677) Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene TBP-associated factor 8 Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene RING/U-box superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional evidence for the critical amino-terminal conserved domain and key amino acids of Arabidopsis 4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE. Hsieh WY, et al. Plant Physiol, 2014 Sep. PMID 25037211, Free PMC Article
    2. The Arabidopsis IspH homolog is involved in the plastid nonmevalonate pathway of isoprenoid biosynthesis. Hsieh MH, et al. Plant Physiol, 2005 Jun. PMID 15863698, Free PMC Article
    3. Characterization of the Arabidopsis clb6 mutant illustrates the importance of posttranscriptional regulation of the methyl-D-erythritol 4-phosphate pathway. Guevara-García A, et al. Plant Cell, 2005 Feb. PMID 15659625, Free PMC Article
    4. Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis. Rutschow H, et al. Plant Physiol, 2008 Sep. PMID 18633119, Free PMC Article
    5. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. critical tyrosine-72 residue in the amino-terminal conserved domain
      Title: Functional evidence for the critical amino-terminal conserved domain and key amino acids of Arabidopsis 4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE.
    2. Arabidopsis HDR contains an extra amino-terminal domain following the transit peptide that is highly conserved from cyanobacteria, and green algae to land plants but not existing in the other bacteria. Tyrosine-72 residue was critical for Arabidopsis HDR.
      Title: Functional evidence for the critical amino-terminal conserved domain and key amino acids of Arabidopsis 4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE.
    3. IspH null mutants having an albino phenotype show that the development of chloroplasts is severely impaired in the IspH-deficient albino tissues. Arabidopsis IspH is involved in plastid isoprenoid biosynthesis. [IspH]
      Title: The Arabidopsis IspH homolog is involved in the plastid nonmevalonate pathway of isoprenoid biosynthesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_119600.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity (ferredoxin) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables 4-hydroxy-3-methylbut-2-enyl diphosphate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4-hydroxy-3-methylbut-2-enyl diphosphate reductase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dimethylallyl diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    4-hydroxy-3-methylbut-2-enyl diphosphate reductase
    NP_567965.1
    • 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (HDR); FUNCTIONS IN: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity, 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity; INVOLVED IN: response to antibiotic, isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway; LOCATED IN: chloroplast stroma, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: LytB protein (InterPro:IPR003451); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16428407..16431144 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119600.4 → NP_567965.1  4-hydroxy-3-methylbut-2-enyl diphosphate reductase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567965.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DHZ9, Q56WI5, Q5EGH0, Q94B35, Q9SZ00
      UniProtKB/TrEMBL
      A0A178V3K9, A0A5S9XZ93, A0A654FVY2
      Conserved Domains (1) summary
      PLN02821
      Location:1 → 465
      PLN02821; 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94B35.1

    Gene LinkOut

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