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    APX5 ascorbate peroxidase 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829751, updated on 18-Sep-2024

    Summary

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    Official Symbol
    APX5
    Official Full Name
    ascorbate peroxidase 5
    Primary source
    TAIR:AT4G35970
    Locus tag
    AT4G35970
    See related
    Araport:AT4G35970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ascorbate peroxidase 5; T19K4.100
    Summary
    Encodes a microsomal ascorbate peroxidase APX5. Ascorbate peroxidases are enzymes that scavenge hydrogen peroxide in plant cells. Eight types of APX have been described for Arabidopsis: three cytosolic (APX1, APX2, APX6), two chloroplastic types (stromal sAPX, thylakoid tAPX), and three microsomal (APX3, APX4, APX5) isoforms.
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    Genomic context

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    See APX5 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    8
    Sequence:
    Chromosome: 4; NC_003075.7 (17028586..17030558)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene RAC-like 6 Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Senescence/dehydration-associated protein-like protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ANKYRIN REPEAT-CONTAINING PROTEIN 2A is an essential molecular chaperone for peroxisomal membrane-bound ASCORBATE PEROXIDASE3 in Arabidopsis. Shen G, et al. Plant Cell, 2010 Mar. PMID 20215589, Free PMC Article
    2. Proteome analysis of peroxisomes from dark-treated senescent Arabidopsis leaves. Pan R, et al. J Integr Plant Biol, 2018 Nov. PMID 29877633
    3. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    4. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001342391.1
    NM_119763.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-ascorbate peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    ascorbate peroxidase 5
    NP_195321.1
    • ascorbate peroxidase 5 (APX5); FUNCTIONS IN: L-ascorbate peroxidase activity, peroxidase activity, heme binding; INVOLVED IN: oxidation reduction, response to oxidative stress; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Haem peroxidase (InterPro:IPR010255), Plant ascorbate peroxidase (InterPro:IPR002207), Peroxidases heam-ligand binding site (InterPro:IPR019793), Peroxidase, active site (InterPro:IPR019794), Haem peroxidase, plant/fungal/bacterial (InterPro:IPR002016); BEST Arabidopsis thaliana protein match is: ascorbate peroxidase 3 (TAIR:AT4G35000.1); Has 11368 Blast hits to 9243 proteins in 1286 species: Archae - 103; Bacteria - 4136; Metazoa - 9; Fungi - 795; Plants - 3885; Viruses - 0; Other Eukaryotes - 2440 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      17028586..17030558
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119763.3 → NP_195321.1  ascorbate peroxidase 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195321.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65634, Q7XZP5
      UniProtKB/TrEMBL
      A0A178V4R4, A0A5S9XZ19, A0A7G2F6D0
      Conserved Domains (1) summary
      PLN02608
      Location:5 → 279
      PLN02608; L-ascorbate peroxidase

    2. NM_001342391.1 → NP_001328787.1  ascorbate peroxidase 5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B5P9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7XZP5.2

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