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    GGT2 gamma-glutamyl transpeptidase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830119, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GGT2
    Official Full Name
    gamma-glutamyl transpeptidase 2
    Primary source
    TAIR:AT4G39650
    Locus tag
    AT4G39650
    See related
    Araport:AT4G39650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    gamma-glutamyl transpeptidase 2; T19P19.40; T19P19_40
    Summary
    The gene encodes a gamma-glutamyltransferase (AKA gamma-glutamyl transpeptidase, EC 2.3.2.2) that is located in the apoplast of young siliques (within the ovules of the carpel) and is involved in the degradation of glutathione. The encoded enzyme also acts as part of a GSH pumping gamma-glutamyl cycle in this tissue and may also be involved in gamma-glutamyl amino acid formation.
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    Genomic context

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    See GGT2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    7
    Sequence:
    Chromosome: 4; NC_003075.7 (18403560..18406025)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene translation initiation factor Neighboring gene gamma-glutamyl transpeptidase 1 Neighboring gene alanine:glyoxylate aminotransferase 2 Neighboring gene Glycolipid transfer protein (GLTP) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Compensatory expression and substrate inducibility of gamma-glutamyl transferase GGT2 isoform in Arabidopsis thaliana. Destro T, et al. J Exp Bot, 2011 Jan. PMID 20959624, Free PMC Article
    2. Gamma-glutamyl transpeptidase in transgenic tobacco plants. Cellular localization, processing, and biochemical properties. Storozhenko S, et al. Plant Physiol, 2002 Mar. PMID 11891265, Free PMC Article
    3. Apoplastic gamma-glutamyl transferase activity encoded by GGT1 and GGT2 is important for vegetative and generative development. Giaretta S, et al. Plant Physiol Biochem, 2017 Jun. PMID 28319794
    4. Characterization of the extracellular gamma-glutamyl transpeptidases, GGT1 and GGT2, in Arabidopsis. Ohkama-Ohtsu N, et al. Plant J, 2007 Mar. PMID 17316175
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study showed that apoplastic GGT silencing induces a decrease in the number of organs with a high GSH demand (seeds and trichomes) as a result of resource reallocation to preserve integrity and composition.
      Title: Apoplastic gamma-glutamyl transferase activity encoded by GGT1 and GGT2 is important for vegetative and generative development.
    2. GGT2 expression is enhanced in ggt1 knockout mutants, suggesting a compensatory effect to restore GGT activity in the root apoplast.
      Title: Compensatory expression and substrate inducibility of gamma-glutamyl transferase GGT2 isoform in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_120125.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables glutathione gamma-glutamylcysteinyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables leukotriene C4 gamma-glutamyl transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within glutathione catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within glutathione catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glutathione transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gamma-glutamyl transpeptidase 2
    NP_195675.2
    • gamma-glutamyl transpeptidase 2 (GGT2); CONTAINS InterPro DOMAIN/s: Gamma-glutamyltranspeptidase (InterPro:IPR000101); BEST Arabidopsis thaliana protein match is: gamma-glutamyl transpeptidase 1 (TAIR:AT4G39640.2); Has 9214 Blast hits to 9192 proteins in 1483 species: Archae - 86; Bacteria - 4248; Metazoa - 714; Fungi - 303; Plants - 110; Viruses - 1; Other Eukaryotes - 3752 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      18403560..18406025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120125.2 → NP_195675.2  gamma-glutamyl transpeptidase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195675.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65653, Q680I5
      UniProtKB/TrEMBL
      A0A654FX12
      Conserved Domains (1) summary
      PLN02198
      Location:5 → 578
      PLN02198; glutathione gamma-glutamylcysteinyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q680I5.1

    Gene LinkOut

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