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    PAT2 protein affected trafficking 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824714, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PAT2
    Official Full Name
    protein affected trafficking 2
    Primary source
    TAIR:AT3G55480
    Locus tag
    AT3G55480
    See related
    Araport:AT3G55480
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AP-3 beta; beta-subunit of adaptor protein complex 3; protein affected trafficking 2; WAT1; WEAK ACID TOLERANT 1
    Summary
    Encodes PAT2, a putative beta-subunit of adaptor protein complex 3 (AP-3) that can partially complement the corresponding yeast mutant. Mediates the biogenesis and function of lytic vacuoles.
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    Genomic context

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    See PAT2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    11
    Sequence:
    Chromosome: 3; NC_003074.8 (20566248..20571248, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene PBS1-like 1 Neighboring gene SC35-like splicing factor 30 Neighboring gene Calcium-dependent lipid-binding (CaLB domain) family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GINS complex protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The AP-3 β adaptin mediates the biogenesis and function of lytic vacuoles in Arabidopsis. Feraru E, et al. Plant Cell, 2010 Aug. PMID 20729380, Free PMC Article
    2. Trafficking of plant vacuolar invertases: from a membrane-anchored to a soluble status. Understanding sorting information in their complex N-terminal motifs. Xiang L, et al. Plant Cell Physiol, 2013 Aug. PMID 23737500
    3. A dominant-negative form of Arabidopsis AP-3 β-adaptin improves intracellular pH homeostasis. Niñoles R, et al. Plant J, 2013 May. PMID 23397991
    4. The ADAPTOR PROTEIN-3 Complex Mediates Pollen Tube Growth by Coordinating Vacuolar Targeting and Organization. Feng QN, et al. Plant Physiol, 2018 May. PMID 29523712, Free PMC Article
    5. Routes to the tonoplast: the sorting of tonoplast transporters in Arabidopsis mesophyll protoplasts. Wolfenstetter S, et al. Plant Cell, 2012 Jan. PMID 22253225, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A role for AP-3 in pollen tube growth.
      Title: The ADAPTOR PROTEIN-3 Complex Mediates Pollen Tube Growth by Coordinating Vacuolar Targeting and Organization.
    2. Vacuolar invertases (VIs) might follow an alternative, adaptor protein 3 (AP3)-dependent route in addition to the classical sorting pathway.
      Title: Trafficking of plant vacuolar invertases: from a membrane-anchored to a soluble status. Understanding sorting information in their complex N-terminal motifs.
    3. The phenotypes of the wat1-1D mutant can be explained if loss of function of the AP-3 beta-adaptin (PAT2) causes activation of channels or transporters for organic anions and for K(+) at the plasma membrane.
      Title: A dominant-negative form of Arabidopsis AP-3 β-adaptin improves intracellular pH homeostasis.
    4. In Arabidopsis plants defective in the beta-subunit of the AP-3 adaptor complex, INT1 is correctly localized to the tonoplast, while sorting of the vacuolar sucrose transporter SUC4 is blocked in cis-Golgi stacks.
      Title: Routes to the tonoplast: the sorting of tonoplast transporters in Arabidopsis mesophyll protoplasts.
    5. Evolutionarily conserved AP-3 beta plays a role in the biogenesis and function of the lytic vacuole.
      Title: The AP-3 β adaptin mediates the biogenesis and function of lytic vacuoles in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_115406.5
    NM_202714.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Golgi to vacuole transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lytic vacuole organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of intracellular pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    protein affected trafficking 2
    NP_567022.1
    • protein affected trafficking 2 (PAT2); FUNCTIONS IN: binding; INVOLVED IN: intracellular protein transport, vesicle-mediated transport; LOCATED IN: membrane coat, endomembrane system; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Armadillo-like helical (InterPro:IPR011989), Armadillo-type fold (InterPro:IPR016024), Clathrin/coatomer adaptor, adaptin-like, N-terminal (InterPro:IPR002553); BEST Arabidopsis thaliana protein match is: Adaptin family protein (TAIR:AT4G11380.1); Has 2700 Blast hits to 1765 proteins in 249 species: Archae - 0; Bacteria - 810; Metazoa - 816; Fungi - 546; Plants - 173; Viruses - 0; Other Eukaryotes - 355 (source: NCBI BLink).
    NP_974443.4
    • protein affected trafficking 2 (PAT2); FUNCTIONS IN: protein transporter activity, binding; INVOLVED IN: intracellular protein transport, vesicle-mediated transport, endocytosis, protein transport; LOCATED IN: membrane coat, Golgi apparatus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Adaptor protein complex AP-3, beta subunit (InterPro:IPR017108), Armadillo-like helical (InterPro:IPR011989), Armadillo-type fold (InterPro:IPR016024), Clathrin/coatomer adaptor, adaptin-like, N-terminal (InterPro:IPR002553); BEST Arabidopsis thaliana protein match is: Adaptin family protein (TAIR:AT4G23460.1); Has 2490 Blast hits to 1771 proteins in 223 species: Archae - 0; Bacteria - 20; Metazoa - 1008; Fungi - 721; Plants - 224; Viruses - 0; Other Eukaryotes - 517 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20566248..20571248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_202714.4 → NP_974443.4  protein affected trafficking 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974443.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VB16, A0A5S9XMS4, F4IWW1
      Conserved Domains (4) summary
      sd00044
      Location:70 → 94
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:47 → 639
      Adaptin_N; Adaptin N terminal region
      pfam14796
      Location:799 → 942
      AP3B1_C; Clathrin-adaptor complex-3 beta-1 subunit C-terminal
      NF033845
      Location:697 → 855
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

    2. NM_115406.5 → NP_567022.1  protein affected trafficking 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567022.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93YS9, Q9M2T1
      UniProtKB/TrEMBL
      A0A178VB16, A0A5S9XMS4
      Conserved Domains (2) summary
      pfam01602
      Location:9 → 511
      Adaptin_N; Adaptin N terminal region
      pfam14796
      Location:671 → 814
      AP3B1_C; Clathrin-adaptor complex-3 beta-1 subunit C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M2T1.2

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