FER1 ferretin 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: FER1
Official Full Name: ferretin 1
Primary source: TAIR:AT5G01600
Locus tag: AT5G01600
See related: Araport:AT5G01600
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA FERRETIN 1; ATFER1; ferretin 1
Summary: Encodes a ferretin protein that is targeted to the chloroplast. Member of a Ferritin gene family. Gene expression is induced in response to iron overload and by nitric oxide. Expression of the gene is downregulated in the presence of paraquat, an inducer of photoxidative stress.
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Genomic context

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See FER1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 8

Sequence:: Chromosome: 5; NC_003076.8 (227953..230051, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fe mediated decrease of lateral root length and density is enhanced in fer1-3-4 triple mutant plants.
Title: Iron- and ferritin-dependent reactive oxygen species distribution: impact on Arabidopsis root system architecture.
phosphate starvation response of AtFer1 is not linked to the iron status of plants and is specifically initiated by phosphate deficiency
Title: Arabidopsis ferritin 1 (AtFer1) gene regulation by the phosphate starvation response 1 (AtPHR1) transcription factor reveals a direct molecular link between iron and phosphate homeostasis.
Data indicate that steady-state mRNA abundance for three representative Fe homeostasis genes, IRT1, bHLH39, and FER1, oscillated in light/dark (LD) cycles or warm/cold environmental cycles.
Title: Reciprocal interaction of the circadian clock with the iron homeostasis network in Arabidopsis.
Data show that a leaf glutathione concentration threshold between 10 and 50 nmol GSHg(-1) FW is required for full induction of AtFer1 gene expression in response to iron.
Title: GSH threshold requirement for NO-mediated expression of the Arabidopsis AtFer1 ferritin gene in response to iron.
new regulatory pathway involved in plant response to oxidative stress was revealed using the iron-induced Arabidopsis ferritin AtFER1 as a model
Title: Iron and ROS control of the DownSTream mRNA decay pathway is essential for plant fitness.
Ferritin accumulation during infection of Arabidopsis by E. chrysanthemi is a basal defense mechanism which is mainly activated by bacterial siderophores.
Title: Siderophore-mediated upregulation of Arabidopsis ferritin expression in response to Erwinia chrysanthemi infection.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_120238.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ferric iron binding	IEA Inferred from Electronic Annotation more info
enables ferroxidase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables iron ion binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within flower development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within iron ion transport	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within leaf development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within photosynthesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cold	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to iron ion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to reactive oxygen species	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to zinc ion	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in chloroplast stroma	HDA more info	PubMed
located_in chloroplast thylakoid membrane	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in thylakoid	HDA more info	PubMed

General protein information

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Preferred Names: ferretin 1

NP_195780.1

ferretin 1 (FER1); FUNCTIONS IN: ferric iron binding, iron ion binding; INVOLVED IN: in 12 processes; LOCATED IN: thylakoid, chloroplast thylakoid membrane, chloroplast stroma, chloroplast, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ferritin, N-terminal (InterPro:IPR001519), Ferritin-related (InterPro:IPR012347), Ferritin-like (InterPro:IPR009040), Ferritin, conserved site (InterPro:IPR014034), Ferritin/ribonucleotide reductase-like (InterPro:IPR009078), Ferritin/Dps protein (InterPro:IPR008331); BEST Arabidopsis thaliana protein match is: ferritin 4 (TAIR:AT2G40300.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).