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    CAX4 cation exchanger 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831754, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CAX4
    Official Full Name
    cation exchanger 4
    Primary source
    TAIR:AT5G01490
    Locus tag
    AT5G01490
    See related
    Araport:AT5G01490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCAX4; cation exchanger 4; F7A7.10; F7A7_10
    Summary
    Encodes a cation/proton antiporter, a member of low affinity calcium antiporter CAX2 family. Involved in root development under metal stress.
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    Genomic context

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    See CAX4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    12
    Sequence:
    Chromosome: 5; NC_003076.8 (195452..198651)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene Cysteine/Histidine-rich C1 domain family protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene thylakoid ATP/ADP carrier Neighboring gene root UVB sensitive protein (Protein of unknown function, DUF647)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Description of AtCAX4 in Response to Abiotic Stress in Arabidopsis. Bu Y, et al. Int J Mol Sci, 2021 Jan 16. PMID 33467091, Free PMC Article
    2. Root development under metal stress in Arabidopsis thaliana requires the H+/cation antiporter CAX4. Mei H, et al. New Phytol, 2009. PMID 19368667
    3. Increased calcium levels and prolonged shelf life in tomatoes expressing Arabidopsis H+/Ca2+ transporters. Park S, et al. Plant Physiol, 2005 Nov. PMID 16244156, Free PMC Article
    4. Characterization of CAX4, an Arabidopsis H(+)/cation antiporter. Cheng NH, et al. Plant Physiol, 2002 Apr. PMID 11950973, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Description of AtCAX4 in Response to Abiotic Stress in Arabidopsis.
      Title: Description of AtCAX4 in Response to Abiotic Stress in Arabidopsis.
    2. In this study, we show that CAX4 is expressed in the root apex and lateral root primordia, and that expression is increased when Ni(2+) or Mn(2+) levels are elevated or Ca(2+) is depleted.
      Title: Root development under metal stress in Arabidopsis thaliana requires the H+/cation antiporter CAX4.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001342594.1
    NM_120227.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium:monoatomic cation antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium:monoatomic cation antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables calcium:proton antiporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables calcium:proton antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plant-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuolar membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cation exchanger 4
    NP_568091.2
    • cation exchanger 4 (CAX4); CONTAINS InterPro DOMAIN/s: Sodium/calcium exchanger membrane region (InterPro:IPR004837), Calcium/proton exchanger superfamily (InterPro:IPR004798), Calcium/proton exchanger (InterPro:IPR004713); BEST Arabidopsis thaliana protein match is: cation exchanger 1 (TAIR:AT2G38170.3); Has 3152 Blast hits to 2978 proteins in 994 species: Archae - 25; Bacteria - 1749; Metazoa - 60; Fungi - 737; Plants - 238; Viruses - 0; Other Eukaryotes - 343 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      195452..198651
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120227.4 → NP_568091.2  cation exchanger 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568091.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FXC4
      Conserved Domains (2) summary
      TIGR00846
      Location:70 → 435
      caca2; calcium/proton exchanger
      pfam01699
      Location:291 → 436
      Na_Ca_ex; Sodium/calcium exchanger protein

    2. NM_001342594.1 → NP_001331104.1  cation exchanger 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FXC4
    Nucleotide Protein
    Heading Accession and Version

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