MTM2 Myotubularin-like phosphatases II superfamily [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: MTM2
Official Full Name: Myotubularin-like phosphatases II superfamily
Primary source: TAIR:AT5G04540
Locus tag: AT5G04540
See related: Araport:AT5G04540
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtMTM2; myotubularin 2; T32M21.150; T32M21_150
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Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

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Arabidopsis myotubularins play a role in the vesicular trafficking between endoplasmic reticulum exit sites and cis-Golgi elements.
Title: Subcellular localizations of Arabidopsis myotubularins MTM1 and MTM2 suggest possible functions in vesicular trafficking between ER and cis-Golgi.
A single amino acid mutation in AtMTM2 results in a dramatic loss of subcellular localization.
Title: Divergent functions of the myotubularin (MTM) homologs AtMTM1 and AtMTM2 in Arabidopsis thaliana: evolution of the plant MTM family.

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NM_120536.5

Function	Evidence Code	Pubs
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3-phosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

NP_196074.2

Myotubularin-like phosphatases II superfamily; FUNCTIONS IN: phosphatase activity, protein tyrosine phosphatase activity; INVOLVED IN: dephosphorylation; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein-tyrosine phosphatase, active site (InterPro:IPR016130), Myotubularin phosphatase (InterPro:IPR017906), GRAM (InterPro:IPR004182), Myotubularin-related (InterPro:IPR010569); BEST Arabidopsis thaliana protein match is: Myotubularin-like phosphatases II superfamily (TAIR:AT3G10550.1); Has 1724 Blast hits to 1576 proteins in 187 species: Archae - 0; Bacteria - 0; Metazoa - 1283; Fungi - 139; Plants - 41; Viruses - 0; Other Eukaryotes - 261 (source: NCBI BLink).

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The following sections contain reference sequences that belong to a specific genome build. Explain