DL1 dynamin-like protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: DL1
Official Full Name: dynamin-like protein
Primary source: TAIR:AT5G42080
Locus tag: AT5G42080
See related: Araport:AT5G42080
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ADL1; ADL1A; AG68; DRP1A; dynamin-like protein; DYNAMIN-RELATED PROTEIN 1A; MJC20.19; MJC20_19; RADIAL SWELLING 9; RSW9
Summary: Encodes a dynamin-like protein related to phragmoplastin. Mutations in this gene, in combination with mutation in ADL1E, result in defects in embryogenesis, cell plate formation and trichome branching. Also controls vascular patterning in combination with VAN3 and GNOM. DRP2B and DRP1A participate together in clathrin-coated vesicle formation during endocytosis.
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Genomic context

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See DL1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 16

Sequence:: Chromosome: 5; NC_003076.8 (16820284..16825016, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study propose that SH3P2 functions together with DRP1A to convert the fused vesicles to tubular structures during cytokinesis.
Title: SH3 Domain-Containing Protein 2 Plays a Crucial Role at the Step of Membrane Tubulation during Cell Plate Formation.
DRP1A is required for boron-induced degradation of BOR1.
Title: DRP1-Dependent Endocytosis is Essential for Polar Localization and Boron-Induced Degradation of the Borate Transporter BOR1 in Arabidopsis thaliana.
DRP1A is required for high membrane lipid order at the cell plate.
Title: High lipid order of Arabidopsis cell-plate membranes mediated by sterol and DYNAMIN-RELATED PROTEIN1A function.
propose that rapid and specific internalization of PIN proteins mediated by the DRP1 proteins and the associated CME machinery from the cell plate membranes during cytokinesis is an important mechanism for proper polar PIN positioning in interphase cells
Title: Cell plate restricted association of DRP1A and PIN proteins is required for cell polarity establishment in Arabidopsis.
DRP2B shares domain organization with animal dynamins whereas DRP1A is plant-specific.
Title: Arabidopsis dynamin-related proteins DRP2B and DRP1A participate together in clathrin-coated vesicle formation during endocytosis.
purified AtDRP1A behaves very differently than purified dynamin, and in ways that are difficult to reconcile with what is known of its in vivo activity, suggesting that additional factors or modifications are needed for AtDRP1A to function.
Title: Arabidopsis dynamin-related protein 1A polymers bind, but do not tubulate, liposomes.
These results indicate that Arabidopsis dynamin-related proteins, DRP1A and DRP2B, from two different families, participate in membrane remodeling at a similar place in the cell plate.
Title: Arabidopsis dynamin-related protein DRP2B is co-localized with DRP1A on the leading edge of the forming cell plate.
DRP1A forms discreet dynamic foci in the epidermal cell cortex and while the foci overlap with those formed by DRP1C and clathrin light chain, there are clear differences in behavior and response to pharmacological inhibitors between DRP1A and DRP1C foci.
Title: Comparison of the dynamics and functional redundancy of the Arabidopsis dynamin-related isoforms DRP1A and DRP1C during plant development.
absence causes impaired endocytosis which may contribute to the development of shorter, fatter roots, probably by reducing cellulose synthesis
Title: Arabidopsis dynamin-like protein DRP1A: a null mutant with widespread defects in endocytosis, cellulose synthesis, cytokinesis, and cell expansion.
DRP1 modulates the VAN3 function in vesicle budding from the trans-Golgi network, which regulates vascular formation in Arabidopsis. [DRP1A]
Title: DRP1A is responsible for vascular continuity synergistically working with VAN3 in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001203519.1

Supported by ESTs:

NM_123573.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables clathrin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein histidine kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell plate formation involved in plant-type cell wall biogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell plate formation involved in plant-type cell wall biogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell plate formation involved in plant-type cell wall biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to boron-containing substance levels	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within clathrin-dependent endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in clathrin-dependent endocytosis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cytokinesis by cell plate formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryo development ending in seed dormancy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of establishment of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipid localization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of phragmoplast microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of plant-type cell wall organization or biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to boron-containing substance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within root hair initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stigma development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trichome branching	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within xylem and phloem pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell plate	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast thylakoid membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with clathrin-coated endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in phragmoplast	IDA Inferred from Direct Assay more info	PubMed
located_in plant-type vacuole	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasmodesma	HDA more info	PubMed
located_in plastid	HDA more info	PubMed

General protein information

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Preferred Names: dynamin-like protein

NP_001190448.1

dynamin-like protein (DL1); CONTAINS InterPro DOMAIN/s: Dynamin GTPase effector (InterPro:IPR003130), Dynamin, GTPase region, conserved site (InterPro:IPR019762), GTPase effector domain, GED (InterPro:IPR020850), Dynamin, GTPase domain (InterPro:IPR001401), Dynamin central region (InterPro:IPR000375); BEST Arabidopsis thaliana protein match is: DYNAMIN-like 1B (TAIR:AT3G61760.1).

NP_568602.3

dynamin-like protein (DL1); FUNCTIONS IN: protein binding, clathrin binding, GTP binding, GTPase activity; INVOLVED IN: in 6 processes; LOCATED IN: in 6 components; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Dynamin, GTPase domain (InterPro:IPR001401), Dynamin, GTPase region, conserved site (InterPro:IPR019762), Dynamin central region (InterPro:IPR000375); BEST Arabidopsis thaliana protein match is: DYNAMIN-like 1B (TAIR:AT3G61760.1); Has 2738 Blast hits to 2718 proteins in 315 species: Archae - 2; Bacteria - 44; Metazoa - 1052; Fungi - 806; Plants - 508; Viruses - 0; Other Eukaryotes - 326 (source: NCBI BLink).

NP_851120.1

dynamin-like protein (DL1); FUNCTIONS IN: protein binding, clathrin binding, GTP binding, GTPase activity; INVOLVED IN: in 6 processes; LOCATED IN: in 6 components; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Dynamin GTPase effector (InterPro:IPR003130), Dynamin, GTPase domain (InterPro:IPR001401), Dynamin, GTPase region, conserved site (InterPro:IPR019762), GTPase effector domain, GED (InterPro:IPR020850), Dynamin central region (InterPro:IPR000375); BEST Arabidopsis thaliana protein match is: DYNAMIN-like 1B (TAIR:AT3G61760.1); Has 2870 Blast hits to 2761 proteins in 321 species: Archae - 2; Bacteria - 66; Metazoa - 1056; Fungi - 810; Plants - 578; Viruses - 0; Other Eukaryotes - 358 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

16820284..16825016 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_180789.3 → NP_851120.1 dynamin-like protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_851120.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P42697, Q0WLG2, Q1EBU0, Q39118, Q8L9V5, Q8LPS7

UniProtKB/TrEMBL

A0A178UEJ4, A0A5S9YAD2

Conserved Domains (3) summary

smart00302
Location:513 → 606

GED; Dynamin GTPase effector domain

cd08771
Location:33 → 300

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:222 → 495

Dynamin_M; Dynamin central region
NM_001344434.1 → NP_001331306.1 dynamin-like protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

P42697, Q0WLG2, Q1EBU0, Q39118, Q8L9V5, Q8LPS7

UniProtKB/TrEMBL

A0A178UEJ4, A0A5S9YAD2

Conserved Domains (3) summary

smart00302
Location:513 → 606

GED; Dynamin GTPase effector domain

cd08771
Location:33 → 300

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:222 → 495

Dynamin_M; Dynamin central region
NM_001203519.1 → NP_001190448.1 dynamin-like protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190448.1

Status: REVIEWED

UniProtKB/TrEMBL

F4K015

Conserved Domains (4) summary

smart00302
Location:507 → 600

GED; Dynamin GTPase effector domain

cd08771
Location:33 → 300

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

COG0699
Location:84 → 318

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

pfam01031
Location:223 → 491

Dynamin_M; Dynamin central region
NM_123573.3 → NP_568602.3 dynamin-like protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_568602.3

Status: REVIEWED

UniProtKB/Swiss-Prot

P42697

Conserved Domains (3) summary

cd08771
Location:33 → 300

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

COG0699
Location:84 → 318

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

pfam01031
Location:223 → 429

Dynamin_M; Dynamin central region