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    MYA2 myosin 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834412, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MYA2
    Official Full Name
    myosin 2
    Primary source
    TAIR:AT5G43900
    Locus tag
    AT5G43900
    See related
    Araport:AT5G43900
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS MYOSIN 2; ATMYA2; F6B6.4; F6B6_4; myosin 2; MYOSIN X1 2; MYOSIN XI-6; XI-2; XI-6
    Summary
    Encodes a member of the type XI myosin protein family that binds F-actin and co-localizes with actin filaments and peroxisomes. Homozygous mutants are reported to have pleiotropic effects in growth and fertility and may also be lethal. This protein is also involved in root hair growth and organelle trafficking. This protein interacts with RabC2a and RabD1 in a GTP-dependent manner.
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    Genomic context

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    See MYA2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    41
    Sequence:
    Chromosome: 5; NC_003076.8 (17656894..17667451, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene methyl-coenzyme M reductase II subunit gamma, putative (DUF3741) Neighboring gene Flavin-binding monooxygenase family protein Neighboring gene pfkB-like carbohydrate kinase family protein Neighboring gene transducin family protein / WD-40 repeat family protein Neighboring gene Transducin family protein / WD-40 repeat family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Autoregulation and dual stepping mode of MYA2, an Arabidopsis myosin XI responsible for cytoplasmic streaming. Haraguchi T, et al. Sci Rep, 2022 Feb 24. PMID 35210477, Free PMC Article
    2. Head-neck domain of Arabidopsis myosin XI, MYA2, fused with GFP produces F-actin patterns that coincide with fast organelle streaming in different plant cells. Walter N, et al. BMC Plant Biol, 2008 Jul 3. PMID 18598361, Free PMC Article
    3. Peroxisomal localization of a myosin XI isoform in Arabidopsis thaliana. Hashimoto K, et al. Plant Cell Physiol, 2005 May. PMID 15792961
    4. Two class XI myosins function in organelle trafficking and root hair development in Arabidopsis. Peremyslov VV, et al. Plant Physiol, 2008 Mar. PMID 18178669, Free PMC Article
    5. Myosins XI-K, XI-1, and XI-2 are required for development of pavement cells, trichomes, and stigmatic papillae in Arabidopsis. Ojangu EL, et al. BMC Plant Biol, 2012 Jun 6. PMID 22672737, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Autoregulation and dual stepping mode of MYA2, an Arabidopsis myosin XI responsible for cytoplasmic streaming.
      Title: Autoregulation and dual stepping mode of MYA2, an Arabidopsis myosin XI responsible for cytoplasmic streaming.
    2. findings establish myosins XI as key regulators of plant antifungal immunity.
      Title: Myosins XI modulate host cellular responses and penetration resistance to fungal pathogens.
    3. The class XI myosins XI-K, XI-1 and XI-2 have partially redundant roles in the growth of shoot epidermis. Myosin XI-K plays more important role whereas myosins XI-1 and XI-2 have minor roles in the determination of size and shape of epidermal cells.
      Title: Myosins XI-K, XI-1, and XI-2 are required for development of pavement cells, trichomes, and stigmatic papillae in Arabidopsis.
    4. analysis of myosin-dependent endoplasmic reticulum motility and F-actin organization in plant cells
      Title: Myosin-dependent endoplasmic reticulum motility and F-actin organization in plant cells.
    5. AtRabD1 and AtRabC2a interact with the C-terminal tail region of MYA2.
      Title: An isoform of Arabidopsis myosin XI interacts with small GTPases in its C-terminal tail region.
    6. The localization of the head of MYA2 in living plant cells suggests a close linkage between this myosin XI and cytoplasmic microfilaments that support the rapid streaming of organelles.
      Title: Head-neck domain of Arabidopsis myosin XI, MYA2, fused with GFP produces F-actin patterns that coincide with fast organelle streaming in different plant cells.
    7. knockouts exhibited defects in root hair elongation suggesting that the myosin-driven motility plays a significant role in a polar tip growth
      Title: Two class XI myosins function in organelle trafficking and root hair development in Arabidopsis.
    8. the peroxisome is one of the cargos translocated by MYA2 on actin filaments
      Title: Peroxisomal localization of a myosin XI isoform in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_123757.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTP-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables cytoskeletal motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Golgi localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within actin filament-based movement TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within gynoecium development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf pavement cell development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    NOT involved_in mitochondrion localization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within mitochondrion localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within peroxisome localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root hair elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within trichome morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    part_of myosin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myosin 2
    NP_001190465.1
    • myosin 2 (MYA2); CONTAINS InterPro DOMAIN/s: Dil domain (InterPro:IPR018444), Dilute (InterPro:IPR002710), Myosin, N-terminal, SH3-like (InterPro:IPR004009), Myosin head, motor domain (InterPro:IPR001609), IQ calmodulin-binding region (InterPro:IPR000048); BEST Arabidopsis thaliana protein match is: myosin XI B (TAIR:AT1G04160.1).
    NP_001190466.1
    • myosin 2 (MYA2); CONTAINS InterPro DOMAIN/s: Dil domain (InterPro:IPR018444), Dilute (InterPro:IPR002710), Myosin, N-terminal, SH3-like (InterPro:IPR004009), Myosin head, motor domain (InterPro:IPR001609), IQ calmodulin-binding region (InterPro:IPR000048); BEST Arabidopsis thaliana protein match is: myosin XI B (TAIR:AT1G04160.1).
    NP_199203.1
    • myosin 2 (MYA2); CONTAINS InterPro DOMAIN/s: Dil domain (InterPro:IPR018444), Dilute (InterPro:IPR002710), Myosin, N-terminal, SH3-like (InterPro:IPR004009), Myosin head, motor domain (InterPro:IPR001609), IQ calmodulin-binding region (InterPro:IPR000048); BEST Arabidopsis thaliana protein match is: myosin XI B (TAIR:AT1G04160.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      17656894..17667451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203537.1 → NP_001190466.1  myosin 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190466.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4K7C4
      Conserved Domains (6) summary
      smart00015
      Location:886 → 908
      IQ; Calmodulin-binding motif
      smart00242
      Location:117 → 787
      MYSc; Myosin. Large ATPases
      cd15475
      Location:1156 → 1532
      MyosinXI_CBD; cargo binding domain of myosin XI
      cd01384
      Location:136 → 776
      MYSc_Myo11; class XI myosin, motor domain
      pfam02736
      Location:73 → 108
      Myosin_N; Myosin N-terminal SH3-like domain
      cl23720
      Location:961 → 1080
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    2. NM_001203536.1 → NP_001190465.1  myosin 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190465.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4K7C5
      Conserved Domains (6) summary
      smart00015
      Location:889 → 911
      IQ; Calmodulin-binding motif
      smart00242
      Location:117 → 790
      MYSc; Myosin. Large ATPases
      cd15475
      Location:1159 → 1535
      MyosinXI_CBD; cargo binding domain of myosin XI
      cd01384
      Location:136 → 779
      MYSc_Myo11; class XI myosin, motor domain
      pfam02736
      Location:73 → 108
      Myosin_N; Myosin N-terminal SH3-like domain
      cl23720
      Location:964 → 1083
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    3. NM_123757.5 → NP_199203.1  myosin 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199203.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WPF0, Q39158, Q9LKB9
      UniProtKB/TrEMBL
      A0A178U9A5, A0A5S9YBB5
      Conserved Domains (5) summary
      smart00015
      Location:829 → 851
      IQ; Calmodulin-binding motif
      COG1196
      Location:870 → 1043
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd15475
      Location:1099 → 1475
      MyosinXI_CBD; cargo binding domain of myosin XI
      cd01384
      Location:76 → 719
      MYSc_Myo11; class XI myosin, motor domain
      pfam02736
      Location:13 → 48
      Myosin_N; Myosin N-terminal SH3-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LKB9.1

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