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    D2HGDH FAD-linked oxidases family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829792, updated on 18-Sep-2024

    Summary

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    Official Symbol
    D2HGDH
    Official Full Name
    FAD-linked oxidases family protein
    Primary source
    TAIR:AT4G36400
    Locus tag
    AT4G36400
    See related
    Araport:AT4G36400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AP22.14; AP22_14; D-2-hydroxyglutarate dehydrogenase
    Summary
    Encodes a (D)-2-hydroxyglutarate dehydrogenase.
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    Genomic context

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    See D2HGDH in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    16
    Sequence:
    Chromosome: 4; NC_003075.7 (17197188..17200932)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 superfamily protein Neighboring gene Methylthiotransferase Neighboring gene Ribosomal protein L12 family protein Neighboring gene ubiquitin-conjugating enzyme 17

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two D-2-hydroxy-acid dehydrogenases in Arabidopsis thaliana with catalytic capacities to participate in the last reactions of the methylglyoxal and beta-oxidation pathways. Engqvist M, et al. J Biol Chem, 2009 Sep 11. PMID 19586914, Free PMC Article
    2. The Arabidopsis electron-transfer flavoprotein:ubiquinone oxidoreductase is required during normal seed development and germination. da Fonseca-Pereira P, et al. Plant J, 2022 Jan. PMID 34741366
    3. D-2-hydroxyglutarate metabolism is linked to photorespiration in the shm1-1 mutant. Kuhn A, et al. Plant Biol (Stuttg), 2013 Jul. PMID 23551974
    4. Identification of the 2-hydroxyglutarate and isovaleryl-CoA dehydrogenases as alternative electron donors linking lysine catabolism to the electron transport chain of Arabidopsis mitochondria. Araújo WL, et al. Plant Cell, 2010 May. PMID 20501910, Free PMC Article
    5. Plants Possess a Cyclic Mitochondrial Metabolic Pathway similar to the Mammalian Metabolic Repair Mechanism Involving Malate Dehydrogenase and l-2-Hydroxyglutarate Dehydrogenase. Hüdig M, et al. Plant Cell Physiol, 2015 Sep. PMID 26203119

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a mitochondrial metabolic repair mechanism in Arabidopsis thaliana involving malate dehydrogenase (mMDH) and l-2-hydroxyglutarate dehydrogenase (l-2HGDH), was characterized.
      Title: Plants Possess a Cyclic Mitochondrial Metabolic Pathway similar to the Mammalian Metabolic Repair Mechanism Involving Malate Dehydrogenase and l-2-Hydroxyglutarate Dehydrogenase.
    2. Data elucidates the pathway of plant Lys catabolism and demonstrate that both isovaleryl-CoA dehydrogenase and 2-hydroxyglutarate dehydrogenase act as electron donors to the ubiquinol pool via an ETF/ETFQO-mediated route. [D2HGDH]
      Title: Identification of the 2-hydroxyglutarate and isovaleryl-CoA dehydrogenases as alternative electron donors linking lysine catabolism to the electron transport chain of Arabidopsis mitochondria.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001342409.1
    NM_202963.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables (R)-2-hydroxyglutarate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2-hydroxyglutarate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2-hydroxyglutarate dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within alternative respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within photorespiration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    FAD-linked oxidases family protein
    NP_001320151.1
    • FAD-linked oxidases family protein; FUNCTIONS IN: electron carrier activity, (R)-2-hydroxyglutarate dehydrogenase activity; INVOLVED IN: biological_process unknown; LOCATED IN: mitochondrion; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: FAD-binding, type 2 (InterPro:IPR016166), FAD-linked oxidase, C-terminal (InterPro:IPR004113), FAD-linked oxidase-like, C-terminal (InterPro:IPR016164), FAD linked oxidase, N-terminal (InterPro:IPR006094), FAD-binding, type 2, subdomain 1 (InterPro:IPR016167); BEST Arabidopsis thaliana protein match is: FAD-linked oxidases family protein (TAIR:AT5G06580.1); Has 16802 Blast hits to 16669 proteins in 1978 species: Archae - 280; Bacteria - 10481; Metazoa - 384; Fungi - 582; Plants - 134; Viruses - 0; Other Eukaryotes - 4941 (source: NCBI BLink).
    NP_974692.1
    • FAD-linked oxidases family protein; FUNCTIONS IN: electron carrier activity, (R)-2-hydroxyglutarate dehydrogenase activity; INVOLVED IN: biological_process unknown; LOCATED IN: mitochondrion; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: FAD-binding, type 2 (InterPro:IPR016166), FAD-linked oxidase, C-terminal (InterPro:IPR004113), FAD-linked oxidase-like, C-terminal (InterPro:IPR016164), FAD linked oxidase, N-terminal (InterPro:IPR006094), FAD-binding, type 2, subdomain 1 (InterPro:IPR016167); BEST Arabidopsis thaliana protein match is: FAD-linked oxidases family protein (TAIR:AT5G06580.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      17197188..17200932
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_202963.2 → NP_974692.1  FAD-linked oxidases family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974692.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23240, Q93Z78
      UniProtKB/TrEMBL
      A0A5S9XZI3, A0A654FW45
      Conserved Domains (1) summary
      COG0277
      Location:102 → 554
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]

    2. NM_001342409.1 → NP_001320151.1  FAD-linked oxidases family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23240, Q93Z78
      UniProtKB/TrEMBL
      A0A5S9XZI3, A0A654FW45
      Conserved Domains (1) summary
      COG0277
      Location:102 → 554
      GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O23240.3

    Gene LinkOut

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