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    RAD51C RAS associated with diabetes protein 51C [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819136, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RAD51C
    Official Full Name
    RAS associated with diabetes protein 51C
    Primary source
    TAIR:AT2G45280
    Locus tag
    AT2G45280
    See related
    Araport:AT2G45280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATRAD51C; F4L23.21; RAS associated with diabetes protein 51C
    Summary
    Encodes a protein similar to RAD51C involved in double stranded break repair via homologous recombination. Sensitive to DSB induced by Mitomycin C and gamma irradiation, interacts with Atxrcc3 in yeast two-hybrid assay. Required for female meiosis but not critical for mitosis under normal conditions.
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    Genomic context

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    See RAD51C in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Sequence:
    Chromosome: 2; NC_003071.7 (18670009..18672469)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene myosin-4 protein (DUF641) Neighboring gene glycoprotease 1 Neighboring gene Transketolase Neighboring gene RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis RAD51C gene is important for homologous recombination in meiosis and mitosis. Abe K, et al. Plant Physiol, 2005 Oct. PMID 16169964, Free PMC Article
    2. The AtRAD51C gene is required for normal meiotic chromosome synapsis and double-stranded break repair in Arabidopsis. Li W, et al. Plant Physiol, 2005 Jun. PMID 15923332, Free PMC Article
    3. Silencing of meiosis-critical genes for engineering male sterility in plants. Wang X, et al. Plant Cell Rep, 2012 Apr. PMID 22120011
    4. Arabidopsis Rad51B is important for double-strand DNA breaks repair in somatic cells. Osakabe K, et al. Plant Mol Biol, 2005 Apr. PMID 15952068
    5. Molecular cloning and characterization of RAD51-like genes from Arabidopsis thaliana. Osakabe K, et al. Plant Mol Biol, 2002 Sep. PMID 12139010

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtRAD51C and SWI may function at distinct stages of meiosis.
      Title: Silencing of meiosis-critical genes for engineering male sterility in plants.
    2. Crossing of RAD51C mutant with wild-type plants showed defective male and female gametogeneses as evidenced by lack of seed production. Furthermore, meiosis was severely disturbed in the mutant.
      Title: Arabidopsis RAD51C gene is important for homologous recombination in meiosis and mitosis.
    3. AtRAD51C is essential for normal meiosis and is probably required for homologous synapsis.[AtRAD51C]
      Title: The AtRAD51C gene is required for normal meiotic chromosome synapsis and double-stranded break repair in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001202820.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA strand exchange activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within double-strand break repair via synthesis-dependent strand annealing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within female meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within somatic cell DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    RAS associated with diabetes protein 51C
    NP_001189749.1
    • RAS associated with diabetes protein 51C (RAD51C); CONTAINS InterPro DOMAIN/s: DNA recombination/repair protein RecA/RadB, ATP-binding domain (InterPro:IPR020588), DNA recombination and repair protein, RecA-like (InterPro:IPR016467), DNA recombination and repair protein Rad51, C-terminal (InterPro:IPR013632); BEST Arabidopsis thaliana protein match is: DNA repair (Rad51) family protein (TAIR:AT3G22880.1).
    NP_566040.1
    • RAS associated with diabetes protein 51C (RAD51C); CONTAINS InterPro DOMAIN/s: DNA recombination/repair protein RecA/RadB, ATP-binding domain (InterPro:IPR020588), DNA recombination and repair protein, RecA-like (InterPro:IPR016467), DNA recombination and repair protein Rad51, C-terminal (InterPro:IPR013632); BEST Arabidopsis thaliana protein match is: DNA repair (Rad51) family protein (TAIR:AT3G22880.1); Has 5546 Blast hits to 5533 proteins in 2007 species: Archae - 678; Bacteria - 2546; Metazoa - 757; Fungi - 474; Plants - 412; Viruses - 0; Other Eukaryotes - 679 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      18670009..18672469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_130091.2 → NP_566040.1  RAS associated with diabetes protein 51C [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566040.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22144, Q8GXF0, Q8RY30, Q93X07, Q9FT75, Q9FT80
      UniProtKB/TrEMBL
      A0A178VVB4, A0A5S9X759, A0A654F245
      Conserved Domains (2) summary
      PRK04301
      Location:27 → 290
      radA; DNA repair and recombination protein RadA; Validated
      cd19492
      Location:123 → 332
      Rad51C; RAD51C recombinase

    2. NM_001202820.1 → NP_001189749.1  RAS associated with diabetes protein 51C [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189749.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654F245, F4IW45
      Conserved Domains (1) summary
      cd01123
      Location:129 → 375
      Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GXF0.2

    Gene LinkOut

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