Crtc2 CREB regulated transcription coactivator 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Crtc2provided by MGI
Official Full Name: CREB regulated transcription coactivator 2provided by MGI
Primary source: MGI:MGI:1921593
See related: Ensembl:ENSMUSG00000027936 AllianceGenome:MGI:1921593
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Torc2; 4632407F12Rik
Summary: Predicted to enable cAMP response element binding protein binding activity; chromatin binding activity; and transcription coactivator activity. Involved in gluconeogenesis; glucose homeostasis; and positive regulation of CREB transcription factor activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; ear; integumental system; limb; and nervous system. Orthologous to human CRTC2 (CREB regulated transcription coactivator 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in spleen adult (RPKM 33.2), thymus adult (RPKM 31.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 39.21 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (90161475..90171432)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (90253858..90264125)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatic noradrenergic innervation acts via CREB/CRTC2 to activate gluconeogenesis during cold.
Title: Hepatic noradrenergic innervation acts via CREB/CRTC2 to activate gluconeogenesis during cold.
CRTC2 activates the epithelial-mesenchymal transition of diabetic kidney disease through the CREB-Smad2/3 pathway.
Title: CRTC2 activates the epithelial-mesenchymal transition of diabetic kidney disease through the CREB-Smad2/3 pathway.
Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress.
Title: Cytoplasmic Endonuclease G promotes nonalcoholic fatty liver disease via mTORC2-AKT-ACLY and endoplasmic reticulum stress.
Osteocytes autophagy mediated by mTORC2 activation controls osteoblasts differentiation and osteoclasts activities under mechanical loading.
Title: Osteocytes autophagy mediated by mTORC2 activation controls osteoblasts differentiation and osteoclasts activities under mechanical loading.
cAMP-Induced Nuclear Condensation of CRTC2 Promotes Transcription Elongation and Cystogenesis in Autosomal Dominant Polycystic Kidney Disease.
Title: cAMP-Induced Nuclear Condensation of CRTC2 Promotes Transcription Elongation and Cystogenesis in Autosomal Dominant Polycystic Kidney Disease.
Endoplasmic reticulum stress downregulates PGC-1alpha in skeletal muscle through ATF4 and an mTOR-mediated reduction of CRTC2.
Title: Endoplasmic reticulum stress downregulates PGC-1α in skeletal muscle through ATF4 and an mTOR-mediated reduction of CRTC2.
IL-1beta-activated mTORC2 promotes accumulation of IFN-gamma(+) gammadelta T cells by upregulating CXCR3 to restrict hepatic fibrosis.
Title: IL-1β-activated mTORC2 promotes accumulation of IFN-γ(+) γδ T cells by upregulating CXCR3 to restrict hepatic fibrosis.
A novel role of CRTC2 in promoting nonalcoholic fatty liver disease.
Title: A novel role of CRTC2 in promoting nonalcoholic fatty liver disease.
Disruption of CRTC1 and CRTC2 in Sim1 cells strongly increases high-fat diet intake in female mice but has a modest impact on male mice.
Title: Disruption of CRTC1 and CRTC2 in Sim1 cells strongly increases high-fat diet intake in female mice but has a modest impact on male mice.
A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB/CRTC2 transcriptional complex.
Title: A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB/CRTC2 transcriptional complex.

Submit: New GeneRIF Correction See all GeneRIFs (45)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Crtc2 (e-PCR), detects polymorphism
- UniSTS:547204

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cAMP response element binding protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP response element binding protein binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to cAMP	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of CREB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein homotetramerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CREB-regulated transcription coactivator 2

Names: TORC-2; transducer of CREB protein 2; transducer of regulated cAMP response element-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357152.2 → NP_001344081.1 CREB-regulated transcription coactivator 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC119825

UniProtKB/TrEMBL

Q3TDX5, Q8R1U3

Related

ENSMUST00000136970.8

Conserved Domains (2) summary

pfam12885
Location:1 → 138

TORC_M; Transducer of regulated CREB activity middle domain

pfam12886
Location:435 → 512

TORC_C; Transducer of regulated CREB activity, C terminus
NM_028881.4 → NP_083157.1 CREB-regulated transcription coactivator 2 isoform 1

See identical proteins and their annotated locations for NP_083157.1

Status: VALIDATED

Source sequence(s)

AC119825

Consensus CDS

CCDS38501.1

UniProtKB/Swiss-Prot

Q3TA52, Q3U182, Q8BH09

Related

ENSMUSP00000029545.9, ENSMUST00000029545.15

Conserved Domains (3) summary

pfam12884
Location:18 → 72

TORC_N; Transducer of regulated CREB activity, N terminus

pfam12885
Location:168 → 317

TORC_M; Transducer of regulated CREB activity middle domain

pfam12886
Location:614 → 691

TORC_C; Transducer of regulated CREB activity, C terminus

RNA

NR_151631.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC119825

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

90161475..90171432

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006502153.1 → XP_006502216.1 CREB-regulated transcription coactivator 2 isoform X2

Conserved Domains (3) summary

pfam12884
Location:18 → 72

TORC_N; Transducer of regulated CREB activity, N-terminus

pfam12885
Location:168 → 317

TORC_M; Transducer of regulated CREB activity middle domain

pfam12886
Location:526 → 603

TORC_C; Transducer of regulated CREB activity, C-terminus
XM_006502152.1 → XP_006502215.1 CREB-regulated transcription coactivator 2 isoform X1

Conserved Domains (3) summary

pfam12884
Location:18 → 72

TORC_N; Transducer of regulated CREB activity, N-terminus

pfam12885
Location:145 → 294

TORC_M; Transducer of regulated CREB activity middle domain

pfam12886
Location:591 → 668

TORC_C; Transducer of regulated CREB activity, C-terminus