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    Clcnka chloride channel, voltage-sensitive Ka [ Mus musculus (house mouse) ]

    Gene ID: 12733, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Clcnkaprovided by MGI
    Official Full Name
    chloride channel, voltage-sensitive Kaprovided by MGI
    Primary source
    MGI:MGI:1329026
    See related
    Ensembl:ENSMUSG00000033770 AllianceGenome:MGI:1329026
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CLC-K1; Clcnk1
    Summary
    This gene is a member of the CLC family of voltage-gated chloride channels. The gene is located adjacent to a highly similar chloride channel gene on chromosome 4. This gene is syntenic with human CLCNKB (geneID:1188). Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Sep 2009]
    Expression
    Restricted expression toward kidney adult (RPKM 38.0) See more
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    Genomic context

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    See Clcnka in Genome Data Viewer
    Location:
    4 D3; 4 73.94 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (141111922..141126017, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (141384611..141398706, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 13076 Neighboring gene family with sequence similarity 131, member C Neighboring gene STARR-positive B cell enhancer ABC_E4697 Neighboring gene predicted gene, 34693 Neighboring gene STARR-positive B cell enhancer ABC_E4698 Neighboring gene chloride channel, voltage-sensitive Kb

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Analysis of NaCl transport in thin ascending limb of Henle's loop in CLC-K1 null mice. Liu W, et al. Am J Physiol Renal Physiol, 2002 Mar. PMID 11832425
    2. Role of ClC-K and barttin in low potassium-induced sodium chloride cotransporter activation and hypertension in mouse kidney. Nomura N, et al. Biosci Rep, 2018 Feb 28. PMID 29326302, Free PMC Article
    3. The ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron. Hennings JC, et al. J Am Soc Nephrol, 2017 Jan. PMID 27335120, Free PMC Article
    4. Characterization of the mouse ClC-K1/Barttin chloride channel. L'Hoste S, et al. Biochim Biophys Acta, 2013 Nov. PMID 23791703
    5. Cl(-) channels in basolateral TAL membranes XV. Molecular heterogeneity between cortical and medullary channels. Winters CJ, et al. J Membr Biol, 2000 Oct 1. PMID 11014860

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. our study provides in vivo evidence that, in response to a low-potassium diet, ClC-K and barttin play important roles in the activation of the WNK4-SPAK-NCC cascade and blood pressure regulation.
      Title: Role of ClC-K and barttin in low potassium-induced sodium chloride cotransporter activation and hypertension in mouse kidney.
    2. molecular substrate of a chloride channel previously detected in the mouse thick ascending limb
      Title: Characterization of the mouse ClC-K1/Barttin chloride channel.
    3. induction of SGK1, CLC-K1 and barttin by high osmolarity and change in intracellular volume in distal renal tubular cells in vivo and in vitro
      Title: High osmolality induces the kidney-specific chloride channel CLC-K1 by a serum and glucocorticoid-inducible kinase 1 MAPK pathway.
    4. Gene expression profiling in the collecting tubules of aquaporin-1 and CLC-Nk1 knockout mice.
      Title: Altered expression profile of transporters in the inner medullary collecting duct of aquaporin-1 knockout mice.
    5. the major component of Cl(-) transport sensitive to NPPB or pH is mediated by CLC-K1 in the tAL.
      Title: Analysis of NaCl transport in thin ascending limb of Henle's loop in CLC-K1 null mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables voltage-gated chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated monoatomic ion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloride transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of body fluid levels IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within renal inner medulla development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transepithelial chloride transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    chloride channel protein ClC-Ka
    Names
    chloride channel K1
    chloride channel Ka
    putative basolateral cTAL chloride channel ClC-Ka

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146307.1 → NP_001139779.1  chloride channel protein ClC-Ka

      See identical proteins and their annotated locations for NP_001139779.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AY373832, BB743618, BG061970, CF725377
      Consensus CDS
      CCDS18871.1
      UniProtKB/Swiss-Prot
      A2ADB3, Q6UB69, Q8JZU7, Q9WUB7
      Related
      ENSMUSP00000101416.2, ENSMUST00000105790.8
      Conserved Domains (3) summary
      cd03683
      Location:49 → 533
      ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
      cd04591
      Location:555 → 676
      CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
      pfam00654
      Location:106 → 514
      Voltage_CLC; Voltage gated chloride channel

    2. NM_024412.3 → NP_077723.3  chloride channel protein ClC-Ka

      See identical proteins and their annotated locations for NP_077723.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AY373832, BB743618, BG061970, CJ068439
      Consensus CDS
      CCDS18871.1
      UniProtKB/Swiss-Prot
      A2ADB3, Q6UB69, Q8JZU7, Q9WUB7
      Related
      ENSMUSP00000048520.8, ENSMUST00000042617.14
      Conserved Domains (3) summary
      cd03683
      Location:49 → 533
      ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
      cd04591
      Location:555 → 676
      CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
      pfam00654
      Location:106 → 514
      Voltage_CLC; Voltage gated chloride channel

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      141111922..141126017 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUB7.2 GenPept UniProtKB/Swiss-Prot:Q9WUB7

    Gene LinkOut

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