Slk STE20-like kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slkprovided by MGI
Official Full Name: STE20-like kinaseprovided by MGI
Primary source: MGI:MGI:103241
See related: Ensembl:ENSMUSG00000025060 AllianceGenome:MGI:103241
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9A2; Etk4; SMAK; Stk2; mSLK; mKIAA0204
Summary: Predicted to enable histone kinase activity; protein homodimerization activity; and protein serine/threonine kinase activity. Involved in regulation of cell migration. Located in cell leading edge. Is expressed in several structures, including alimentary system; genitourinary system; musculature; nervous system; and sensory organ. Orthologous to human SLK (STE20 like kinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 14.8), placenta adult (RPKM 11.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3- D1; 19 39.77 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (47568458..47633685)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (47580019..47645246)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of a kinase inactive SLK is embryonic lethal and impairs cell migration in fibroblasts.
Title: Expression of a kinase inactive SLK is embryonic lethal and impairs cell migration in fibroblasts.
Role of the Ste20-like kinase SLK in podocyte adhesion.
Title: Role of the Ste20-like kinase SLK in podocyte adhesion.
Ste20-like kinase activity promotes meiotic resumption and spindle microtubule stability in mouse oocytes.
Title: Ste20-like kinase activity promotes meiotic resumption and spindle microtubule stability in mouse oocytes.
Ste20-like Kinase Is Critical for Inhibitory Synapse Maintenance and Its Deficiency Confers a Developmental Dendritopathy.
Title: Ste20-like Kinase Is Critical for Inhibitory Synapse Maintenance and Its Deficiency Confers a Developmental Dendritopathy.
Muscle-specific deletion of SLK/Stk2 enhances p38 activity and myogenesis in mdx mice.
Title: Muscle-specific deletion of SLK/Stk2 enhances p38 activity and myogenesis in mdx mice.
Loss of the Ste20-like kinase induces a basal/stem-like phenotype in HER2-positive breast cancers.
Title: Loss of the Ste20-like kinase induces a basal/stem-like phenotype in HER2-positive breast cancers.
Genetic ablation of SLK exacerbates glomerular injury in adriamycin nephrosis in mice.
Title: Genetic ablation of SLK exacerbates glomerular injury in adriamycin nephrosis in mice.
Podocyte-specific deletion of SLK leads to albuminuria, loss of podocytes, and morphological evidence of podocyte injury. Thus, SLK is essential to the maintenance of podocyte integrity.
Title: Ste20-like kinase, SLK, a novel mediator of podocyte integrity.
Loss of SLK impairs myofiber stability and function.
Title: Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness.
kinases, including Slk, Lok and Mst1, are inhibited by BI-D1870 but to a much lesser extent by BIX 02565 and that phosphorylation of some of their substrates is blocked by BI-D1870 in living cells.
Title: A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW411554 (e-PCR)
- UniSTS:181255

RH126377 (e-PCR)
- UniSTS:163085

AV021402 (e-PCR)
- UniSTS:186159

D19Dcr42 (e-PCR), detects polymorphism
- UniSTS:532362

D19Dcr43 (e-PCR), detects polymorphism
- UniSTS:532363

D19Dcr44 (e-PCR), detects polymorphism
- UniSTS:532364

NoName (e-PCR)
- UniSTS:237972

D19Dcr97 (e-PCR), detects polymorphism
- UniSTS:546500

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone kinase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic microtubule organization	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of focal adhesion assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell leading edge	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: STE20-like serine/threonine-protein kinase

Names: STE20-related kinase SMAK; STE20-related serine/threonine-protein kinase; serine/threonine-protein kinase 2

NP_001158111.1

EC 2.7.11.1

NP_033315.2

EC 2.7.11.1

XP_006526890.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164639.1 → NP_001158111.1 STE20-like serine/threonine-protein kinase isoform 2

See identical proteins and their annotated locations for NP_001158111.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AC125075, AK029491, AK037798, AK051969, CD740818, CO431234

Consensus CDS

CCDS50465.1

UniProtKB/TrEMBL

A2RRK3

Related

ENSMUSP00000026043.6, ENSMUST00000026043.12

Conserved Domains (3) summary

smart00220
Location:34 → 292

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06643
Location:28 → 309

STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase

pfam12474
Location:987 → 1127

PKK; Polo kinase kinase
NM_009289.3 → NP_033315.2 STE20-like serine/threonine-protein kinase isoform 1

See identical proteins and their annotated locations for NP_033315.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC125075, AK029491, AK037798, AK051969, CA535951, CD740818, CF748583, CO431234

Consensus CDS

CCDS38017.1

UniProtKB/Swiss-Prot

A2RRK4, O54988, Q80U65, Q8CAU2, Q8CDW2, Q9WU41

Related

ENSMUSP00000049977.8, ENSMUST00000051691.8

Conserved Domains (3) summary

smart00220
Location:34 → 292

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06643
Location:28 → 309

STKc_SLK; Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase

pfam12474
Location:1018 → 1158

PKK; Polo kinase kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

47568458..47633685

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526827.5 → XP_006526890.1 STE20-like serine/threonine-protein kinase isoform X1

Conserved Domains (3) summary

PTZ00121
Location:284 → 1112

PTZ00121; MAEBL; Provisional

pfam12474
Location:942 → 1082

PKK; Polo kinase kinase

cl21453
Location:1 → 233

PKc_like; Protein Kinases, catalytic domain