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    brd2.S bromodomain containing 2 S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 394399, updated on 4-Jan-2025

    Summary

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    Official Symbol
    brd2.S
    Official Full Name
    bromodomain containing 2 S homeolog
    Primary source
    Xenbase:XB-GENE-865469
    Locus tag
    XELAEV_18042427mg
    See related
    EnsemblRapid:ENSXLAG00005007962 AllianceGenome:Xenbase:XB-GENE-865469
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    fsh; nat; brd2; rnf3; fsrg1; ring3; brd2-a
    Summary
    Predicted to act upstream of or within chromatin organization. Predicted to be located in chromosome and nucleus. Human ortholog(s) of this gene implicated in B-cell lymphoma; B-lymphoblastic leukemia/lymphoma; juvenile myoclonic epilepsy; and photosensitivity disease. Orthologous to human BRD2 (bromodomain containing 2). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See brd2.S in Genome Data Viewer
    Location:
    chromosome: 8S
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8S NC_054386.1 (80765807..80779502, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8S NC_030739.1 (78385358..78398930, complement)

    Chromosome 8S - NC_054386.1Genomic Context describing neighboring genes Neighboring gene retinoid X receptor beta S homeolog Neighboring gene collagen type XI alpha 2 S homeolog Neighboring gene major histocompatibility complex, class II, DM alpha S homeolog Neighboring gene HAUS augmin like complex subunit 3 gene 2 S homeolog Neighboring gene proteasome subunit beta 9 S homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    bromodomain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      80765807..80779502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018233213.2 → XP_018088702.1  bromodomain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8J0TR00
      Related
      ENSXLAP00005022810.1, ENSXLAT00005023512.1

    2. XM_018233212.2 → XP_018088701.1  bromodomain-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8J0TR00
      Related
      ENSXLAP00005022793.1, ENSXLAT00005023495.1

    3. XM_018233211.2 → XP_018088700.1  bromodomain-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8J0TQ06

    4. XM_018233210.2 → XP_018088699.1  bromodomain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A1L8F3L2, A0A974H6B8
      Related
      ENSXLAP00005022774.1, ENSXLAT00005023476.1

    5. XM_041575225.1 → XP_041431159.1  bromodomain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8J1LPL3
      Conserved Domains (3) summary
      cd05498
      Location:223 → 324
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:490 → 554
      BET; Bromodomain extra-terminal - transcription regulation
      cl02556
      Location:1 → 60
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    Nucleotide Protein Strain
    Heading Accession and Version

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