U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    flnc.L filamin C L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 734178, updated on 4-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    flnc.L
    Official Full Name
    filamin C L homeolog
    Primary source
    Xenbase:XB-GENE-866270
    Locus tag
    XELAEV_18017912mg
    See related
    EnsemblRapid:ENSXLAG00005032133 AllianceGenome:Xenbase:XB-GENE-866270
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    flnc
    Summary
    Predicted to enable actin filament binding activity. Predicted to act upstream of or within actin cytoskeleton organization. Predicted to be located in intracellular membraneless organelle. Human ortholog(s) of this gene implicated in distal myopathy 4; hypertrophic cardiomyopathy 26; and myofibrillar myopathy 5. Orthologous to human FLNC (filamin C). [provided by Alliance of Genome Resources, Jan 2025]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See flnc.L in Genome Data Viewer
    Location:
    chromosome: 3L
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3L NC_054375.1 (93053777..93105890)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3L NC_030728.1 (77729945..77782154)

    Chromosome 3L - NC_054375.1Genomic Context describing neighboring genes Neighboring gene smoothened, frizzled class receptor L homeolog Neighboring gene tetraspanin 33 L homeolog Neighboring gene coiled-coil domain containing 136 L homeolog Neighboring gene ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F L homeolog Neighboring gene sperm microtubule inner protein 1 L homeolog

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membraneless organelle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    filamin-C
    Names
    filamin C, gamma

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      93053777..93105890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041586606.1 → XP_041442540.1  filamin-C isoform X2

      UniProtKB/TrEMBL
      A0A8J1MNB1
      Related
      ENSXLAP00005096494.1, ENSXLAT00005098269.1
      Conserved Domains (2) summary
      smart00557
      Location:1485 → 1578
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5069
      Location:34 → 260
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

    2. XM_041586607.1 → XP_041442541.1  filamin-C isoform X3

      UniProtKB/TrEMBL
      A0A8J1MM93
      Related
      ENSXLAP00005096728.1, ENSXLAT00005098508.1
      Conserved Domains (3) summary
      smart00557
      Location:1443 → 1536
      IG_FLMN; Filamin-type immunoglobulin domains
      cd21310
      Location:22 → 146
      CH_FLNC_rpt1; first calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins
      cd21314
      Location:150 → 264
      CH_FLNC_rpt2; second calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins

    3. XM_018252798.2 → XP_018108287.1  filamin-C isoform X4

      UniProtKB/TrEMBL
      A0A1L8GZU4, A0A974DE31

    4. XM_041586605.1 → XP_041442539.1  filamin-C isoform X1

      UniProtKB/TrEMBL
      A0A8J1ML92
      Conserved Domains (2) summary
      smart00557
      Location:1485 → 1578
      IG_FLMN; Filamin-type immunoglobulin domains
      COG5069
      Location:34 → 260
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.