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    hand1.L heart and neural crest derivatives expressed 1 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 373663, updated on 4-Jan-2025

    Summary

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    Official Symbol
    hand1.L
    Official Full Name
    heart and neural crest derivatives expressed 1 L homeolog
    Primary source
    Xenbase:XB-GENE-865344
    Locus tag
    XELAEV_18016946mg
    See related
    EnsemblRapid:ENSXLAG00005000925 AllianceGenome:Xenbase:XB-GENE-865344
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    eHAND; hand1; hand-1; hand1-A
    Summary
    Predicted to enable DNA binding activity and protein dimerization activity. Predicted to be located in nucleolus. Is expressed in cardiovascular system; dermal system; mesoderm; musculoskeletal system; and pharyngeal arch. Orthologous to human HAND1 (heart and neural crest derivatives expressed 1). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See hand1.L in Genome Data Viewer
    Location:
    chromosome: 3L
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3L NC_054375.1 (28327699..28334345)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3L NC_030728.1 (15393542..15400396)

    Chromosome 3L - NC_054375.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121401429 Neighboring gene uncharacterized LOC108710837 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC121401430 Neighboring gene SAP30-like L homeolog Neighboring gene polypeptide N-acetylgalactosaminyltransferase 10 L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Xenopus eHAND: a marker for the developing cardiovascular system of the embryo that is regulated by bone morphogenetic proteins. Sparrow DB, et al. Mech Dev, 1998 Feb. PMID 9507100
    2. Asymmetrically reduced expression of hand1 homeologs involving a single nucleotide substitution in a cis-regulatory element. Ochi H, et al. Dev Biol, 2017 May 15. PMID 28359808
    3. Constitutive over-expression of VEGF results in reduced expression of Hand-1 during cardiac development in Xenopus. Nagao K, et al. Biochem Biophys Res Commun, 2007 Aug 3. PMID 17544370
    4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a single nucleotide substitution in the hand1.S promoter was responsible for the reduced expression in the heart.
      Title: Asymmetrically reduced expression of hand1 homeologs involving a single nucleotide substitution in a cis-regulatory element.
    2. increased vascular endothelial growth factor(170) levels disturb Hand-1 expression in the region required for normal heart morphogenesis
      Title: Constitutive over-expression of VEGF results in reduced expression of Hand-1 during cardiac development in Xenopus.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    heart- and neural crest derivatives-expressed protein 1
    Names
    extraembryonic tissues, heart, autonomic nervous system and neural crest derivatives-expressed protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085659.1 → NP_001079128.1  heart- and neural crest derivatives-expressed protein 1

      See identical proteins and their annotated locations for NP_001079128.1

      Status: PROVISIONAL

      Source sequence(s)
      Z95080
      UniProtKB/Swiss-Prot
      O73615
      UniProtKB/TrEMBL
      A0A974DAM3, A0A974HQ95, B7ZRJ2
      Conserved Domains (1) summary
      cl00081
      Location:80 → 139
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      28327699..28334345
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041584858.1 → XP_041440792.1  heart- and neural crest derivatives-expressed protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O73615
      UniProtKB/TrEMBL
      A0A974DAM3, A0A974HQ95, B7ZRJ2
      Related
      ENSXLAP00005002791.1, ENSXLAT00005002842.1
      Conserved Domains (1) summary
      cl00081
      Location:80 → 139
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O73615.1 GenPept UniProtKB/Swiss-Prot:O73615

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.