Ptf1a pancreas associated transcription factor 1a [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptf1aprovided by RGD
Official Full Name: pancreas associated transcription factor 1aprovided by RGD
Primary source: RGD:621709
See related: EnsemblRapid:ENSRNOG00000016902 AllianceGenome:RGD:621709
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in exocrine pancreas development and regulation of DNA-templated transcription. Located in cytoplasm and nucleus. Part of transcription regulator complex. Human ortholog(s) of this gene implicated in pancreatic agenesis 2. Orthologous to human PTF1A (pancreas associated transcription factor 1a). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 8.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.3

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (86959621..86961475)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (82051281..82053135)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (86199623..86201477)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

combined expression of key genes (Pdx1 and p48) involved in pancreatic development may be a promising approach to generate mature pancreatic exocrine cells.
Title: Viral-mediated coexpression of Pdx1 and p48 regulates exocrine pancreatic differentiation in mouse ES cells.
The ability of truncated versions of Hes1 to bind Ptf1-p48 correlates with their ability to down-regulate the activity of the PTF1 transcriptional complex.
Title: Interactions between hairy/enhancer of split-related proteins and the pancreatic transcription factor Ptf1-p48 modulate function of the PTF1 transcriptional complex.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ptf1a (e-PCR), detects polymorphism
- UniSTS:546562

Ptf1a (e-PCR), detects polymorphism
- UniSTS:274187

Ptf1a (e-PCR), detects polymorphism
- UniSTS:516532

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within amacrine cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in amacrine cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in amacrine cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in cerebellum development	ISO Inferred from Sequence Orthology more info
involved_in cerebellum development	ISS Inferred from Sequence or Structural Similarity more info
involved_in developmental process	IBA Inferred from Biological aspect of Ancestor more info
involved_in exocrine pancreas development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within generation of neurons	ISO Inferred from Sequence Orthology more info
involved_in generation of neurons	ISO Inferred from Sequence Orthology more info
involved_in generation of neurons	ISS Inferred from Sequence or Structural Similarity more info
involved_in hindbrain development	ISO Inferred from Sequence Orthology more info
involved_in hindbrain development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pancreas development	ISO Inferred from Sequence Orthology more info
involved_in pancreas development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of neural retina development	ISO Inferred from Sequence Orthology more info
involved_in regulation of neural retina development	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in retina layer formation	ISO Inferred from Sequence Orthology more info
involved_in retina layer formation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within retina morphogenesis in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in tissue development	ISO Inferred from Sequence Orthology more info
involved_in tissue development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pancreas transcription factor 1 subunit alpha

Names: PTF1-p48; bHLH transcription factor p48; p48 DNA-binding subunit of transcription factor PTF1; pancreas specific transcription factor, 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053964.2 → NP_446416.1 pancreas transcription factor 1 subunit alpha

See identical proteins and their annotated locations for NP_446416.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

Q64305

UniProtKB/TrEMBL

A6JMA2

Related

ENSRNOP00000022727.1, ENSRNOT00000022727.4

Conserved Domains (1) summary

cd11417
Location:164 → 218

bHLH_TS_PTF1A; basic helix-loop-helix (bHLH) domain found in pancreas transcription factor 1 subunit alpha (PTF1A) and similar proteins