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    Rinl Ras and Rab interactor-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292760, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rinlprovided by RGD
    Official Full Name
    Ras and Rab interactor-likeprovided by RGD
    Primary source
    RGD:1310133
    See related
    EnsemblRapid:ENSRNOG00000025354 AllianceGenome:RGD:1310133
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310133
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to act upstream of or within endocytosis. Predicted to be located in actin cytoskeleton and ruffle. Predicted to be active in cytosol and endocytic vesicle. Orthologous to human RINL (Ras and Rab interactor like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 42.1), Spleen (RPKM 20.4) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rinl in Genome Data Viewer
    Location:
    1q21
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (93204543..93215851)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (84077011..84088590)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (86971997..86983306)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MARCKS-related protein-like Neighboring gene uncharacterized LOC134483092 Neighboring gene NFKB inhibitor beta Neighboring gene sirtuin 2 Neighboring gene heterogeneous nuclear ribonucleoprotein L Neighboring gene enoyl-CoA hydratase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rin-like, a novel regulator of endocytosis, acts as guanine nucleotide exchange factor for Rab5a and Rab22. Woller B, et al. Biochim Biophys Acta, 2011 Jun. PMID 21419809, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras and Rab interactor-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106241.2 → NP_001099711.1  ras and Rab interactor-like protein

      See identical proteins and their annotated locations for NP_001099711.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6J9L1, D3ZP73
      Related
      ENSRNOP00000034246.3, ENSRNOT00000036907.6
      Conserved Domains (2) summary
      pfam02204
      Location:417 → 519
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl15255
      Location:43 → 136
      SH2; Src homology 2 (SH2) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      93204543..93215851
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006228653.5 → XP_006228715.1  ras and Rab interactor-like protein isoform X1

      Conserved Domains (2) summary
      pfam02204
      Location:521 → 623
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl15255
      Location:147 → 240
      SH2; Src homology 2 (SH2) domain

    2. XM_006228655.5 → XP_006228717.1  ras and Rab interactor-like protein isoform X2

      Conserved Domains (2) summary
      cl15255
      Location:147 → 240
      SH2; Src homology 2 (SH2) domain
      cl19569
      Location:521 → 579
      VPS9; Vacuolar sorting protein 9 (VPS9) domain

    3. XM_006228656.5 → XP_006228718.1  ras and Rab interactor-like protein isoform X5

      Conserved Domains (2) summary
      cl15255
      Location:147 → 240
      SH2; Src homology 2 (SH2) domain
      cl19569
      Location:521 → 562
      VPS9; Vacuolar sorting protein 9 (VPS9) domain

    4. XM_006228657.4 → XP_006228719.1  ras and Rab interactor-like protein isoform X6

      Related
      ENSRNOP00000106412.1, ENSRNOT00000139379.1
      Conserved Domains (2) summary
      pfam02204
      Location:411 → 513
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl15255
      Location:37 → 130
      SH2; Src homology 2 (SH2) domain

    5. XM_063283399.1 → XP_063139469.1  ras and Rab interactor-like protein isoform X3

      UniProtKB/TrEMBL
      A0A0G2K4Y9
      Related
      ENSRNOP00000073226.2, ENSRNOT00000078156.3

    6. XM_039104237.2 → XP_038960165.1  ras and Rab interactor-like protein isoform X4

      UniProtKB/TrEMBL
      A6J9L1, D3ZP73
      Conserved Domains (2) summary
      pfam02204
      Location:417 → 519
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl15255
      Location:43 → 136
      SH2; Src homology 2 (SH2) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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