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    Crls1 cardiolipin synthase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366196, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Crls1provided by RGD
    Official Full Name
    cardiolipin synthase 1provided by RGD
    Primary source
    RGD:1311037
    See related
    EnsemblRapid:ENSRNOG00000021273 AllianceGenome:RGD:1311037
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311037
    Summary
    Enables cardiolipin synthase (CMP-forming). Involved in response to phosphatidylethanolamine and response to thyroxine. Located in mitochondrial membrane. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 57. Orthologous to human CRLS1 (cardiolipin synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 247.2), Kidney (RPKM 226.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Crls1 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (140572680..140591543)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (120119822..120138674)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (125503638..125522460)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 6 non-catalytic subunit Neighboring gene minichromosome maintenance 8 homologous recombination repair factor Neighboring gene leucine rich repeat neuronal 4 Neighboring gene FERM domain containing kindlin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Effect of thyroxine on the activity of mitochondrial cardiolipin synthase in rat liver. Hostetler KY. Biochim Biophys Acta, 1991 Oct 15. PMID 1659453
    2. Solubilization, purification, and characterization of cardiolipin synthase from rat liver mitochondria. Demonstration of its phospholipid requirement. Schlame M, et al. J Biol Chem, 1991 Nov 25. PMID 1657995
    3. Effects of siRNA-dependent knock-down of cardiolipin synthase and tafazzin on mitochondria and proliferation of glioma cells. Ohlig T, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2018 Apr. PMID 29325722
    4. Shotgun lipidomics reveals the temporally dependent, highly diversified cardiolipin profile in the mammalian brain: temporally coordinated postnatal diversification of cardiolipin molecular species with neuronal remodeling. Cheng H, et al. Biochemistry, 2008 May 27. PMID 18454555, Free PMC Article
    5. Metabolism and function of mitochondrial cardiolipin. Ren M, et al. Prog Lipid Res, 2014 Jul. PMID 24769127

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knock-down of cardiolipin synthase affected the cellular CL content in the presence of linoleic acid (LA) in the culture medium.
      Title: Effects of siRNA-dependent knock-down of cardiolipin synthase and tafazzin on mitochondria and proliferation of glioma cells.
    2. CL has roles in in neuronal signaling, mitochondrial bioenergetics, and apoptosis
      Title: Shotgun lipidomics reveals the temporally dependent, highly diversified cardiolipin profile in the mammalian brain: temporally coordinated postnatal diversification of cardiolipin molecular species with neuronal remodeling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cardiolipin synthase (CMP-forming) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cardiolipin synthase (CMP-forming) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cardiolipin synthase (CMP-forming) ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cardiolipin synthase (CMP-forming) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiolipin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cardiolipin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cardiolipin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to phosphatidylethanolamine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to thyroxine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cardiolipin synthase (CMP-forming)
    Names
    CLS
    cardiolipin synthetase
    NP_001014280.1
    XP_006235140.1
    XP_006235141.1
    XP_006235142.1
    XP_063140355.1
    XP_063140356.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014258.1 → NP_001014280.1  cardiolipin synthase (CMP-forming)

      See identical proteins and their annotated locations for NP_001014280.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085849
      UniProtKB/Swiss-Prot
      Q5U2V5
      UniProtKB/TrEMBL
      A6HQH5
      Related
      ENSRNOP00000028900.5, ENSRNOT00000028900.8
      Conserved Domains (1) summary
      COG0558
      Location:107 → 297
      PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      140572680..140591543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284285.1 → XP_063140355.1  cardiolipin synthase (CMP-forming) isoform X3

    2. XM_006235080.5 → XP_006235142.1  cardiolipin synthase (CMP-forming) isoform X2

      See identical proteins and their annotated locations for XP_006235142.1

      Conserved Domains (1) summary
      PLN02794
      Location:1 → 174
      PLN02794; cardiolipin synthase

    3. XM_006235078.5 → XP_006235140.1  cardiolipin synthase (CMP-forming) isoform X1

      See identical proteins and their annotated locations for XP_006235140.1

      Conserved Domains (1) summary
      PLN02794
      Location:10 → 189
      PLN02794; cardiolipin synthase

    4. XM_006235079.5 → XP_006235141.1  cardiolipin synthase (CMP-forming) isoform X2

      See identical proteins and their annotated locations for XP_006235141.1

      Conserved Domains (1) summary
      PLN02794
      Location:1 → 174
      PLN02794; cardiolipin synthase

    5. XM_063284286.1 → XP_063140356.1  cardiolipin synthase (CMP-forming) isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2V5.1 GenPept UniProtKB/Swiss-Prot:Q5U2V5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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