Hhip Hedgehog-interacting protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hhipprovided by RGD
Official Full Name: Hedgehog-interacting proteinprovided by RGD
Primary source: RGD:1564108
See related: EnsemblRapid:ENSRNOG00000018268 AllianceGenome:RGD:1564108
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564108
Summary: Predicted to enable hedgehog family protein binding activity and zinc ion binding activity. Involved in negative regulation of apoptotic process. Predicted to be located in cell surface and plasma membrane. Biomarker of diabetic neuropathy and primary biliary cholangitis. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease. Orthologous to human HHIP (hedgehog interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 167.1), Brain (RPKM 46.0) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (44768038..44856878)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (27863684..27952528)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (31525134..31614487)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH141770 (e-PCR)
- UniSTS:223763

BI302228 (e-PCR)
- UniSTS:247626

RH138698 (e-PCR)
- UniSTS:220785

RH142844 (e-PCR)
- UniSTS:232091

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hedgehog family protein binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within animal organ morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dorsal/ventral pattern formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	ISO Inferred from Sequence Orthology more info
involved_in skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hedgehog-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191817.1 → NP_001178746.1 hedgehog-interacting protein precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

D3ZGL3

Related

ENSRNOP00000100240.1, ENSRNOT00000123732.1

Conserved Domains (2) summary

pfam03024
Location:38 → 220

Folate_rec; Folate receptor family

pfam07995
Location:226 → 428

GSDH; Glucose / Sorbosone dehydrogenase