Chm CHM Rab escort protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Chmprovided by RGD
Official Full Name: CHM Rab escort proteinprovided by RGD
Primary source: RGD:2340
See related: EnsemblRapid:ENSRNOG00000000161 AllianceGenome:RGD:2340
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables small GTPase binding activity. Involved in protein geranylgeranylation. Part of Rab-protein geranylgeranyltransferase complex. Human ortholog(s) of this gene implicated in choroideremia. Orthologous to human CHM (CHM Rab escort protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 114.1), Kidney (RPKM 95.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq31

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (82395463..82554249, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (78203200..78361996, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (84666900..84821775, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RabGGTase has evolved from a GGTase-I-like molecule that 'learned' to interact with a recycling factor (GDI) that, in turn, eventually gave rise to REP1.
Title: Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation.

Submit: New GeneRIF Correction

General gene information

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Markers

DXWox24 (e-PCR)
- UniSTS:517809

BF386272 (e-PCR)
- UniSTS:243650

DXWox25 (e-PCR)
- UniSTS:517851

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GDP-dissociation inhibitor activity	IEA Inferred from Electronic Annotation more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IDA Inferred from Direct Assay more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein geranylgeranylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein geranylgeranylation	ISO Inferred from Sequence Orthology more info
involved_in protein geranylgeranylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein targeting to membrane	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Rab-protein geranylgeranyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Rab-protein geranylgeranyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of Rab-protein geranylgeranyltransferase complex	IEA Inferred from Electronic Annotation more info
part_of Rab-protein geranylgeranyltransferase complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of Rab-protein geranylgeranyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of Rab-protein geranylgeranyltransferase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rab proteins geranylgeranyltransferase component A 1

Names: CHM, Rab escort protein 1; REP-1; choroideraemia protein homolog; choroideremia (Rab escort protein 1); choroideremia protein homolog; choroidermia; rab escort protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001433732.1 → NP_001420661.1 rab proteins geranylgeranyltransferase component A 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021
NM_017067.2 → NP_058763.2 rab proteins geranylgeranyltransferase component A 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

Related

ENSRNOP00000000174.7, ENSRNOT00000000174.9

RNA

NR_197594.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

82395463..82554249 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099489.2 → XP_038955417.1 rab proteins geranylgeranyltransferase component A 1 isoform X1

UniProtKB/TrEMBL

A0A8I6AG68

Conserved Domains (1) summary

cl21454
Location:149 → 457

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins