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    HEN2 RNA helicase, ATP-dependent, SK12/DOB1 protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 815269, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HEN2
    Official Full Name
    RNA helicase, ATP-dependent, SK12/DOB1 protein
    Primary source
    TAIR:AT2G06990
    Locus tag
    AT2G06990
    See related
    Araport:AT2G06990
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    hua enhancer 2; T4E14.10; T4E14_10
    Summary
    encodes a putative DExH-box RNA helicase that acts redundantly with HEN1, HUA1, and HUA2 in the specification of floral organ identity in the third whorl.
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    Genomic context

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    See HEN2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    16
    Sequence:
    Chromosome: 2; NC_003071.7 (2894904..2902020)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene miscRNA Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene kinase with adenine nucleotide alpha hydrolases-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis SMN2/HEN2, Encoding DEAD-Box RNA Helicase, Governs Proper Expression of the Resistance Gene SMN1/RPS6 and Is Involved in Dwarf, Autoimmune Phenotypes of mekk1 and mpk4 Mutants. Takagi M, et al. Plant Cell Physiol, 2020 Aug 1. PMID 32467981
    2. New members of the floral organ identity AGAMOUS pathway. Jack T. Trends Plant Sci, 2002 Jul. PMID 12119159
    3. HUA ENHANCER2, a putative DExH-box RNA helicase, maintains homeotic B and C gene expression in Arabidopsis. Western TL, et al. Development, 2002 Apr. PMID 11923195, Free PMC Article
    4. SERRATE interacts with the nuclear exosome targeting (NEXT) complex to degrade primary miRNA precursors in Arabidopsis. Bajczyk M, et al. Nucleic Acids Res, 2020 Jul 9. PMID 32449937, Free PMC Article
    5. MTR4, a putative RNA helicase and exosome co-factor, is required for proper rRNA biogenesis and development in Arabidopsis thaliana. Lange H, et al. Plant J, 2011 Oct. PMID 21682783

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis SMN2/HEN2, Encoding DEAD-Box RNA Helicase, Governs Proper Expression of the Resistance Gene SMN1/RPS6 and Is Involved in Dwarf, Autoimmune Phenotypes of mekk1 and mpk4 Mutants.
      Title: Arabidopsis SMN2/HEN2, Encoding DEAD-Box RNA Helicase, Governs Proper Expression of the Resistance Gene SMN1/RPS6 and Is Involved in Dwarf, Autoimmune Phenotypes of mekk1 and mpk4 Mutants.
    2. SERRATE interacts with the nuclear exosome targeting (NEXT) complex to degrade primary miRNA precursors in Arabidopsis.
      Title: SERRATE interacts with the nuclear exosome targeting (NEXT) complex to degrade primary miRNA precursors in Arabidopsis.
    3. We show that the Arabidopsis core exosome can associate with two related RNA helicases, AtMTR4 and HEN2
      Title: The RNA helicases AtMTR4 and HEN2 target specific subsets of nuclear transcripts for degradation by the nuclear exosome in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_126675.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within RNA metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within specification of floral organ identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA helicase, ATP-dependent, SK12/DOB1 protein
    NP_565338.1
    • hua enhancer 2 (HEN2); CONTAINS InterPro DOMAIN/s: DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), DSH, C-terminal (InterPro:IPR012961), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), RNA helicase, ATP-dependent, SK12/DOB1 (InterPro:IPR016438), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: RNA helicase, ATP-dependent, SK12/DOB1 protein (TAIR:AT1G59760.1); Has 9841 Blast hits to 8173 proteins in 1240 species: Archae - 753; Bacteria - 3176; Metazoa - 1197; Fungi - 1159; Plants - 489; Viruses - 32; Other Eukaryotes - 3035 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      2894904..2902020
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126675.3 → NP_565338.1  RNA helicase, ATP-dependent, SK12/DOB1 protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565338.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q941F4, Q9ZVW2
      UniProtKB/TrEMBL
      A0A178VT15, A0A5S9WXJ8, A0A7G2E7R3
      Conserved Domains (1) summary
      COG4581
      Location:34 → 995
      Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZVW2.2

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