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    GSTZ1 glutathione S-transferase zeta 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 814770, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GSTZ1
    Official Full Name
    glutathione S-transferase zeta 1
    Primary source
    TAIR:AT2G02390
    Locus tag
    AT2G02390
    See related
    Araport:AT2G02390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATGSTZ1; AtMAAI; GLUTATHIONE S-TRANSFERASE 18; glutathione S-transferase zeta 1; GST18; MAAI; maleylacetoacetate isomerase; T16F16.18; T16F16_18
    Summary
    Encodes glutathione transferase belonging to the zeta class of GSTs. Naming convention according to Wagner et al. (2002). The protein undergoes spontaneous thiolation following treatment with the oxidant tert-butylhydroperoxide. It functions in vitro as a maleylacetoacetate isomerase and is likely to be involved in tyrosine catabolism.
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    Genomic context

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    See GSTZ1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Sequence:
    Chromosome: 2; NC_003071.7 (628730..631165)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene SNARE associated Golgi protein family Neighboring gene glutathione S-transferase (class zeta) 2 Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein Neighboring gene yacP-like NYN domain protein Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of the catalytic activity of Arabidopsis thaliana glutathione transferase zeta class-1 by saturation mutagenesis. Chen D, et al. Biosci Biotechnol Biochem, 2010. PMID 20622445
    2. Identifying functional residues in arabidopsis thaliana zeta class glutathione S-transferase through screening inactive point mutants. Chen X, et al. Biochemistry (Mosc), 2010 Jan. PMID 20331431
    3. Enzymes of tyrosine catabolism in Arabidopsis thaliana. Dixon DP, et al. Plant Sci, 2006 Sep. PMID 22980205
    4. Probing the diversity of the Arabidopsis glutathione S-transferase gene family. Wagner U, et al. Plant Mol Biol, 2002 Jul. PMID 12090627
    5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the specific shape of the active site in AtGSTZ-1 is essential to its activity
      Title: Evolution of the catalytic activity of Arabidopsis thaliana glutathione transferase zeta class-1 by saturation mutagenesis.
    2. The mutants W15R, C19Y, R22H/K83E, P61S, S73P, S109P, and Q112R were found to have activity lower than 1% of the wild-type.
      Title: Identifying functional residues in arabidopsis thaliana zeta class glutathione S-transferase through screening inactive point mutants.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001335107.1
    NM_126296.5
    NM_179595.5
    NM_201671.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables maleylacetoacetate isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aromatic amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within homogentisate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within toxin catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutathione S-transferase zeta 1
    NP_178344.1
    • glutathione S-transferase zeta 1 (GSTZ1); FUNCTIONS IN: glutathione transferase activity, catalytic activity; INVOLVED IN: toxin catabolic process; LOCATED IN: cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Maleylacetoacetate isomerase (InterPro:IPR005955), Glutathione S-transferase, C-terminal (InterPro:IPR004046), Glutathione S-transferase/chloride channel, C-terminal (InterPro:IPR017933), Glutathione S-transferase, N-terminal (InterPro:IPR004045), Glutathione S-transferase, C-terminal-like (InterPro:IPR010987), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: glutathione S-transferase (class zeta) 2 (TAIR:AT2G02380.1); Has 17196 Blast hits to 17170 proteins in 1512 species: Archae - 0; Bacteria - 9185; Metazoa - 2216; Fungi - 532; Plants - 2070; Viruses - 0; Other Eukaryotes - 3193 (source: NCBI BLink).
    NP_849926.2
    • glutathione S-transferase zeta 1 (GSTZ1); FUNCTIONS IN: glutathione transferase activity, catalytic activity; INVOLVED IN: toxin catabolic process; LOCATED IN: cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Maleylacetoacetate isomerase (InterPro:IPR005955), Glutathione S-transferase, C-terminal-like (InterPro:IPR010987), Glutathione S-transferase/chloride channel, C-terminal (InterPro:IPR017933), Glutathione S-transferase, N-terminal (InterPro:IPR004045), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: glutathione S-transferase (class zeta) 2 (TAIR:AT2G02380.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_973400.1
    • glutathione S-transferase zeta 1 (GSTZ1); FUNCTIONS IN: glutathione transferase activity, catalytic activity; INVOLVED IN: toxin catabolic process; LOCATED IN: cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Maleylacetoacetate isomerase (InterPro:IPR005955), Glutathione S-transferase, C-terminal (InterPro:IPR004046), Glutathione S-transferase/chloride channel, C-terminal (InterPro:IPR017933), Glutathione S-transferase, N-terminal (InterPro:IPR004045), Glutathione S-transferase, C-terminal-like (InterPro:IPR010987), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: glutathione S-transferase (class zeta) 2 (TAIR:AT2G02380.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      628730..631165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126296.5 → NP_178344.1  glutathione S-transferase zeta 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178344.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WWK7, Q9ZVQ3
      UniProtKB/TrEMBL
      A0A178VW78, A0A5S9WWJ6, A0A7G2EAW8
      Conserved Domains (1) summary
      TIGR01262
      Location:10 → 217
      maiA; maleylacetoacetate isomerase

    2. NM_201671.3 → NP_973400.1  glutathione S-transferase zeta 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973400.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2EAT9
      Conserved Domains (3) summary
      cd03191
      Location:101 → 220
      GST_C_Zeta; C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases
      cd03042
      Location:9 → 88
      GST_N_Zeta; GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
      TIGR01262
      Location:10 → 224
      maiA; maleylacetoacetate isomerase

    3. NM_179595.5 → NP_849926.2  glutathione S-transferase zeta 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849926.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VWM4, A0A7G2EAW8, F4IQD1
      Conserved Domains (2) summary
      cd03042
      Location:9 → 81
      GST_N_Zeta; GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
      cl02776
      Location:94 → 186
      GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

    4. NM_001335107.1 → NP_001325193.1  glutathione S-transferase zeta 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B2F0, A0A7G2EAW8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZVQ3.1

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