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    CDA1 cytidine deaminase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816476, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CDA1
    Official Full Name
    cytidine deaminase 1
    Primary source
    TAIR:AT2G19570
    Locus tag
    AT2G19570
    See related
    Araport:AT2G19570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AT-CDA1; cytidine deaminase 1; CYTIDINE DEAMINASE 1; DESZ; F3P11.17; F3P11_17
    Summary
    Encodes a cytidine deaminase that deaminates cytidine and deoxycytidine and is competitively inhibited by cytosine-containing compounds.
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    Genomic context

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    See CDA1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_003071.7 (8470244..8471644, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Transducin family protein / WD-40 repeat family protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene proteasome family protein Neighboring gene ncRNA Neighboring gene tetraspanin2 Neighboring gene ncRNA Neighboring gene ACC oxidase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of Arabidopsis thaliana cytidine deaminase. Wang J, et al. Biochem Biophys Res Commun, 2020 Aug 27. PMID 32736689
    2. Of the Nine Cytidine Deaminase-Like Genes in Arabidopsis, Eight Are Pseudogenes and Only One Is Required to Maintain Pyrimidine Homeostasis in Vivo. Chen M, et al. Plant Physiol, 2016 Jun. PMID 27208239, Free PMC Article
    3. A prokaryotic-type cytidine deaminase from Arabidopsis thaliana gene expression and functional characterization. Faivre-Nitschke SE, et al. Eur J Biochem, 1999 Aug. PMID 10469156
    4. Cloning, expression, and purification of cytidine deaminase from Arabidopsis thaliana. Vincenzetti S, et al. Protein Expr Purif, 1999 Feb. PMID 10024464
    5. Pyrimidine catabolism is required to prevent the accumulation of 5-methyluridine in RNA. Gao S, et al. Nucleic Acids Res, 2023 Aug 11. PMID 37334828, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crystal structure of Arabidopsis thaliana cytidine deaminase.
      Title: Crystal structure of Arabidopsis thaliana cytidine deaminase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_127515.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cytidine deaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytidine deaminase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytidine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cytidine deamination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cytidine deaminase 1
    NP_179547.1
    • cytidine deaminase 1 (CDA1); CONTAINS InterPro DOMAIN/s: Cytidine deaminase, homodimeric (InterPro:IPR006263), APOBEC/CMP deaminase, zinc-binding (InterPro:IPR016192), CMP/dCMP deaminase, zinc-binding (InterPro:IPR002125), Cytidine deaminase-like (InterPro:IPR016193), Cytidine/deoxycytidylate deaminase, zinc-binding domain (InterPro:IPR013171); BEST Arabidopsis thaliana protein match is: Cytidine/deoxycytidylate deaminase family protein (TAIR:AT4G29610.1); Has 2638 Blast hits to 2526 proteins in 1057 species: Archae - 42; Bacteria - 2022; Metazoa - 110; Fungi - 58; Plants - 130; Viruses - 0; Other Eukaryotes - 276 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      8470244..8471644 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127515.4 → NP_179547.1  cytidine deaminase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179547.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65896, Q8LEF2, Q9XEX5
      UniProtKB/TrEMBL
      A0A178VLA3, A0A5S9WZC7, A0A654EU82
      Conserved Domains (1) summary
      PLN02402
      Location:1 → 301
      PLN02402; cytidine deaminase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O65896.1

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