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    MUR3 Exostosin family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816556, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MUR3
    Official Full Name
    Exostosin family protein
    Primary source
    TAIR:AT2G20370
    Locus tag
    AT2G20370
    See related
    Araport:AT2G20370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtMUR3; F11A3.8; F11A3_8; KAM1; KATAMARI 1; MURUS 3; RSA3; SHORT ROOT IN SALT MEDIUM 3
    Summary
    Encodes a xyloglucan galactosyltransferase located in the membrane of Golgi stacks that is involved in the biosynthesis of fucose. It is also involved in endomembrane organization. It is suggested that it is a dual-function protein that is responsible for actin organization and the synthesis of cell wall materials.
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    Genomic context

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    See MUR3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_003071.7 (8791939..8794401)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein Neighboring gene uncharacterized protein Neighboring gene Galactose oxidase/kelch repeat superfamily protein Neighboring gene cytochrome oxidase complex assembly protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A bi-functional xyloglucan galactosyltransferase is an indispensable salt stress tolerance determinant in Arabidopsis. Li W, et al. Mol Plant, 2013 Jul. PMID 23571490
    2. Characterization of Arabidopsis mur3 mutations that result in constitutive activation of defence in petioles, but not leaves. Tedman-Jones JD, et al. Plant J, 2008 Dec. PMID 18657237
    3. The MUR3 gene of Arabidopsis encodes a xyloglucan galactosyltransferase that is evolutionarily related to animal exostosins. Madson M, et al. Plant Cell, 2003 Jul. PMID 12837954, Free PMC Article
    4. Rapid structural phenotyping of plant cell wall mutants by enzymatic oligosaccharide fingerprinting. Lerouxel O, et al. Plant Physiol, 2002 Dec. PMID 12481058, Free PMC Article
    5. KATAMARI1/MURUS3 Is a novel golgi membrane protein that is required for endomembrane organization in Arabidopsis. Tamura K, et al. Plant Cell, 2005 Jun. PMID 15863516, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Normal growth was restored in the mur3-3 mutant overexpressing XLT2 and in mur3-3 xxt double mutants when the dysfunctional xyloglucan was modified by doubling the amounts of galactosylated side chains.
      Title: Galactose-depleted xyloglucan is dysfunctional and leads to dwarfism in Arabidopsis.
    2. RSA3/MUR3/KAM1 along with other cell wall-associated proteins plays a critical role in salt stress tolerance
      Title: A bi-functional xyloglucan galactosyltransferase is an indispensable salt stress tolerance determinant in Arabidopsis.
    3. Mur3 knockout mutants upregulate defense-related genes, increase production of salicylic acid and reactive oxygen intermediates, and can resist fungal infection in petioles.
      Title: Characterization of Arabidopsis mur3 mutations that result in constitutive activation of defence in petioles, but not leaves.
    4. KAM1/MUR3 is a novel component of the Golgi-mediated organization of actin functioning in proper endomembrane organization and cell elongation.[MUR3] [KAM1]
      Title: KATAMARI1/MURUS3 Is a novel golgi membrane protein that is required for endomembrane organization in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_127596.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables glycosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within endomembrane system organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within fucose biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within salicylic acid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within unidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within xyloglucan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in Golgi apparatus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi trans cisterna HDA PubMed 
    located_in endosome HDA PubMed 
    located_in trans-Golgi network HDA PubMed 

    General protein information

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    Preferred Names
    Exostosin family protein
    NP_179627.2
    • MURUS 3 (MUR3); CONTAINS InterPro DOMAIN/s: Exostosin-like (InterPro:IPR004263); BEST Arabidopsis thaliana protein match is: Exostosin family protein (TAIR:AT2G29040.1); Has 481 Blast hits to 480 proteins in 27 species: Archae - 0; Bacteria - 0; Metazoa - 8; Fungi - 4; Plants - 455; Viruses - 0; Other Eukaryotes - 14 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      8791939..8794401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127596.3 → NP_179627.2  Exostosin family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179627.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WWH9, Q494P2, Q7XJ98, Q9SK65, W8QNZ0
      UniProtKB/TrEMBL
      A0A178VTY1, A0A5S9WZW3, A0A654EUJ0
      Conserved Domains (1) summary
      pfam03016
      Location:150 → 489
      Exostosin; Exostosin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7XJ98.1

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