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    FH8 formin 8 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843350, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FH8
    Official Full Name
    formin 8
    Primary source
    TAIR:AT1G70140
    Locus tag
    AT1G70140
    See related
    Araport:AT1G70140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATFH8; F20P5.14; F20P5_14; formin 8
    Summary
    Encodes a group I formin. Binds to F-actin barbed ends. Has severing actin filaments activity. Binds profilin. Involved in the initiation and tip growth of root hairs through regulation of actin cytoskeleton.
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    Genomic context

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    See FH8 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (26412500..26415258, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene transmembrane protein, putative (DUF1163) Neighboring gene Concanavalin A-like lectin protein kinase family protein Neighboring gene zinc ion binding protein Neighboring gene zinc finger MYND domain protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and functional characterization of a formin-like protein (AtFH8) from Arabidopsis. Yi K, et al. Plant Physiol, 2005 Jun. PMID 15923338, Free PMC Article
    2. Arabidopsis group Ie formins localize to specific cell membrane domains, interact with actin-binding proteins and cause defects in cell expansion upon aberrant expression. Deeks MJ, et al. New Phytol, 2005 Dec. PMID 16313636
    3. Formin homology 2 domains occur in multiple contexts in angiosperms. Cvrcková F, et al. BMC Genomics, 2004 Jul 15. PMID 15256004, Free PMC Article
    4. Formins: intermediates in signal-transduction cascades that affect cytoskeletal reorganization. Deeks MJ, et al. Trends Plant Sci, 2002 Nov. PMID 12417149
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_105682.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables profilin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within cell tip growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    formin 8
    NP_177171.1
    • formin 8 (FH8); FUNCTIONS IN: actin binding, profilin binding, actin filament binding; INVOLVED IN: actin nucleation, cell tip growth; LOCATED IN: cell-cell junction, plasma membrane; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Actin-binding FH2/DRF autoregulatory (InterPro:IPR003104), Actin-binding FH2 (InterPro:IPR015425); BEST Arabidopsis thaliana protein match is: formin homologue 4 (TAIR:AT1G24150.1); Has 22376 Blast hits to 12386 proteins in 831 species: Archae - 31; Bacteria - 2621; Metazoa - 7710; Fungi - 2231; Plants - 6132; Viruses - 1038; Other Eukaryotes - 2613 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      26412500..26415258 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105682.3 → NP_177171.1  formin 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177171.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04532
      UniProtKB/TrEMBL
      A0A5S9WSW7
      Conserved Domains (1) summary
      smart00498
      Location:297 → 714
      FH2; Formin Homology 2 Domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O04532.1

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