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    NP1 NPK1-related protein kinase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837421, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NP1
    Official Full Name
    NPK1-related protein kinase 1
    Primary source
    TAIR:AT1G09000
    Locus tag
    AT1G09000
    See related
    Araport:AT1G09000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ANP1; F7G19.13; F7G19_13; MAP KINASE KINASE KINASE 1; MAPKKK1; NPK1-related protein kinase 1
    Summary
    NPK1-related protein kinase 1S
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    Genomic context

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    See NP1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    17
    Sequence:
    Chromosome: 1; NC_003070.9 (2891019..2895182)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene AP2/B3-like transcriptional factor family protein Neighboring gene plant glycogenin-like starch initiation protein 5 Neighboring gene glycoside hydrolase family 2 protein Neighboring gene sucrose nonfermenting-like protein Neighboring gene nuclear factor Y, subunit B4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The intracellular ROS accumulation in elicitor-induced immunity requires the multiple organelle-targeted Arabidopsis NPK1-related protein kinases. Marti L, et al. Plant Cell Environ, 2021 Mar. PMID 33314180
    2. An Arabidopsis mitogen-activated protein kinase kinase kinase gene family encodes essential positive regulators of cytokinesis. Krysan PJ, et al. Plant Cell, 2002 May. PMID 12034900, Free PMC Article
    3. Possible involvement of differential splicing in regulation of the activity of Arabidopsis ANP1 that is related to mitogen-activated protein kinase kinase kinases (MAPKKKs). Nishihama R, et al. Plant J, 1997 Jul. PMID 9263451
    4. Phosphorylation of a mitotic kinesin-like protein and a MAPKKK by cyclin-dependent kinases (CDKs) is involved in the transition to cytokinesis in plants. Sasabe M, et al. Proc Natl Acad Sci U S A, 2011 Oct 25. PMID 22006334, Free PMC Article
    5. Functional analysis of oxidative stress-activated mitogen-activated protein kinase cascade in plants. Kovtun Y, et al. Proc Natl Acad Sci U S A, 2000 Mar 14. PMID 10717008, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The intracellular ROS accumulation in elicitor-induced immunity requires the multiple organelle-targeted Arabidopsis NPK1-related protein kinases.
      Title: The intracellular ROS accumulation in elicitor-induced immunity requires the multiple organelle-targeted Arabidopsis NPK1-related protein kinases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_100771.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables MAP kinase kinase kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity HDA PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within flower development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within protein autophosphorylation HDA PubMed 
    acts_upstream_of_or_within response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    NPK1-related protein kinase 1
    NP_563832.2
    • NPK1-related protein kinase 1 (NP1); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase-like domain (InterPro:IPR011009), Mitogen activated protein kinase kinase kinase 3 (InterPro:IPR015748), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: NPK1-related protein kinase 2 (TAIR:AT1G54960.1); Has 134800 Blast hits to 132536 proteins in 4716 species: Archae - 154; Bacteria - 14967; Metazoa - 50642; Fungi - 13331; Plants - 33399; Viruses - 553; Other Eukaryotes - 21754 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      2891019..2895182
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001331801.1 → NP_001323260.1  NPK1-related protein kinase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WGG3, A0A1P8AWJ5

    2. NM_100771.4 → NP_563832.2  NPK1-related protein kinase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563832.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04030, O22039, O22040, Q8GZ05
      UniProtKB/TrEMBL
      A0A178WFH4
      Conserved Domains (2) summary
      smart00220
      Location:69 → 331
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06606
      Location:68 → 331
      STKc_MAPKKK; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase Kinase Kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O22040.2

    Gene LinkOut

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