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    midasin-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843032, updated on 18-Sep-2024

    Summary

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    Official Full Name
    midasin-like protein
    Primary source
    TAIR:AT1G67120
    Locus tag
    AT1G67120
    See related
    Araport:AT1G67120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtMDN1; F5A8.11; F5A8_11; MDN1; MIDASIN 1
    Summary
    Represents a homolog of the yeast MDN gene, which encodes a non-ribosomal protein involved in the maturation and assembly of the 60S ribosomal subunit. In Arabidopsis, it is essential for female gametogenesis progression.
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    75
    Sequence:
    Chromosome: 1; NC_003070.9 (25069428..25095638, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene cytochrome P450, family 735, subfamily A, polypeptide 2 Neighboring gene F-box family protein Neighboring gene HEAT repeat-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coordination between MIDASIN 1-mediated ribosome biogenesis and auxin modulates plant development. Li K, et al. J Exp Bot, 2021 Mar 29. PMID 33476386
    2. The Mutation of Glu at Amino Acid 3838 of AtMDN1 Provokes Pleiotropic Developmental Phenotypes in Arabidopsis. Li PC, et al. Sci Rep, 2016 Nov 8. PMID 27824150, Free PMC Article
    3. The AAA-ATPase MIDASIN 1 Functions in Ribosome Biogenesis and Is Essential for Embryo and Root Development. Li PC, et al. Plant Physiol, 2019 May. PMID 30755475, Free PMC Article
    4. The MIDASIN and NOTCHLESS genes are essential for female gametophyte development in Arabidopsis thaliana. Chantha SC, et al. Physiol Mol Biol Plants, 2010 Jan. PMID 23572950, Free PMC Article
    5. Proteomic study of the Arabidopsis thaliana chloroplastic envelope membrane utilizing alternatives to traditional two-dimensional electrophoresis. Froehlich JE, et al. J Proteome Res, 2003 Jul-Aug. PMID 12938931

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Coordination between MIDASIN 1-mediated ribosome biogenesis and auxin modulates plant development.
      Title: Coordination between MIDASIN 1-mediated ribosome biogenesis and auxin modulates plant development.
    2. MDN1 expression and role in ribosome biogenesis.MDN1 is essential for embryo development.
      Title: The AAA-ATPase MIDASIN 1 Functions in Ribosome Biogenesis and Is Essential for Embryo and Root Development.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001334273.1
    NM_105382.7

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo sac development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo sac development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ribosomal large subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast envelope HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    midasin-like protein
    NP_176883.5
    • ATPases;nucleotide binding;ATP binding;nucleoside-triphosphatases;transcription factor binding; FUNCTIONS IN: nucleoside-triphosphatase activity, ATPase activity, transcription factor binding, nucleotide binding, ATP binding; INVOLVED IN: regulation of transcription, DNA-dependent, regulation of protein complex assembly; LOCATED IN: chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Midasin (InterPro:IPR012099), ATPase, AAA-5 (InterPro:IPR011704), ATPase, AAA+ type, core (InterPro:IPR003593), von Willebrand factor, type A (InterPro:IPR002035), RNA polymerase sigma factor 54, interaction (InterPro:IPR002078); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      25069428..25095638 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105382.7 → NP_176883.5  midasin-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176883.5

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WSP8
      Conserved Domains (8) summary
      cd00009
      Location:655 → 692
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      COG5271
      Location:825 → 5391
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam03028
      Location:2260 → 2328
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam07728
      Location:1074 → 1210
      AAA_5; AAA domain (dynein-related subfamily)
      pfam13238
      Location:2092 → 2156
      AAA_18; AAA domain
      cl00057
      Location:5119 → 5391
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl21455
      Location:1364 → 1587
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
      cl22451
      Location:4684 → 4819
      ASF1_hist_chap; ASF1 like histone chaperone

    2. NM_001334273.1 → NP_001322748.1  midasin-like protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1P8AUY4, B0FU84, F4HRR8, Q0WV24, Q9ZW94
      UniProtKB/TrEMBL
      A0A654ERV0
      Conserved Domains (4) summary
      cl00057
      Location:5126 → 5398
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl26761
      Location:352 → 2344
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cl27032
      Location:4673 → 5015
      Utp14; Utp14 protein
      cl28246
      Location:4689 → 4831
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A1P8AUY4.1

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