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    E2F3 E2F transcription factor 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818174, updated on 18-Sep-2024

    Summary

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    Official Symbol
    E2F3
    Official Full Name
    E2F transcription factor 3
    Primary source
    TAIR:AT2G36010
    Locus tag
    AT2G36010
    See related
    Araport:AT2G36010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATE2FA; E2F transcription factor 3; E2F TRANSCRIPTION FACTOR-3 E2F3; F11F19.8; F11F19_8
    Summary
    Member of the E2F transcription factors, (cell cycle genes), key components of the cyclin D/retinoblastoma/E2F pathway.
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    Genomic context

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    See E2F3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    15
    Sequence:
    Chromosome: 2; NC_003071.7 (15119516..15123184)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Putative lysine decarboxylase family protein Neighboring gene Mitochondrial transcription termination factor family protein Neighboring gene HVA22-like protein J Neighboring gene Ovate family protein Neighboring gene uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtE2F-a and AtDP-a, members of the E2F family of transcription factors, induce Arabidopsis leaf cells to re-enter S phase. Rossignol P, et al. Mol Genet Genomics, 2002 Feb. PMID 11862494
    2. E2Fb and E2Fa transcription factors independently regulate the DNA damage response after ultraviolet B exposure in Arabidopsis. Gómez MS, et al. Plant J, 2022 Mar. PMID 34859915
    3. Arabidopsis E2F1 binds a sequence present in the promoter of S-phase-regulated gene AtCDC6 and is a member of a multigene family with differential activities. de Jager SM, et al. Plant Mol Biol, 2001 Nov. PMID 11669580
    4. Interplay between Arabidopsis activating factors E2Fb and E2Fa in cell cycle progression and development. Sozzani R, et al. Plant Physiol, 2006 Apr. PMID 16514015, Free PMC Article
    5. AtEDT1/HDG11 regulates stomatal density and water-use efficiency via ERECTA and E2Fa. Guo XY, et al. New Phytol, 2019 Aug. PMID 31004497

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EDT1/HDG11-ERECTA-E2Fa genetic pathway that reduces stomatal density by increasing cell size and provide a new avenue to improve water use efficiency of crops.[E2Fa]
      Title: AtEDT1/HDG11 regulates stomatal density and water-use efficiency via ERECTA and E2Fa.
    2. The E2Fa transcription factor of Arabidopsis thaliana is an essential component that regulates the asymmetric cell division marking lateral root initiation.
      Title: Auxin-dependent cell cycle reactivation through transcriptional regulation of Arabidopsis E2Fa by lateral organ boundary proteins.
    3. Overlap between CYCD3;1 and E2Fa modulated genes substantiates their action in a common pathway with a key role in controlling the G1/S transition, with additional targets for E2Fa in cell wall biogenesis and development.
      Title: Dissecting regulatory pathways of G1/S control in Arabidopsis: common and distinct targets of CYCD3;1, E2Fa and E2Fc.
    4. AtE2Fa and AtE2Fb have specific expression patterns and may play similar but distinct roles during cell cycle progression.
      Title: Interplay between Arabidopsis activating factors E2Fb and E2Fa in cell cycle progression and development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    NM_129160.4
    NM_201881.2
    NM_201882.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA damage sensor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of meiotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E2F transcription factor 3
    NP_565831.3
    • E2F transcription factor 3 (E2F3); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent; LOCATED IN: transcription factor complex, chloroplast; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Transcription factor E2F/dimerisation partner (TDP) (InterPro:IPR003316), E2F Family (InterPro:IPR015633); BEST Arabidopsis thaliana protein match is: E2F transcription factor 1 (TAIR:AT5G22220.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_973610.1
    • E2F transcription factor 3 (E2F3); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent; LOCATED IN: transcription factor complex, chloroplast; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Transcription factor E2F/dimerisation partner (TDP) (InterPro:IPR003316), E2F Family (InterPro:IPR015633); BEST Arabidopsis thaliana protein match is: E2F transcription factor 1 (TAIR:AT5G22220.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_973611.1
    • E2F transcription factor 3 (E2F3); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent; LOCATED IN: transcription factor complex, chloroplast; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor E2F/dimerisation partner (TDP) (InterPro:IPR003316), Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), E2F Family (InterPro:IPR015633); BEST Arabidopsis thaliana protein match is: E2F transcription factor 1 (TAIR:AT5G22220.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      15119516..15123184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_201882.3 → NP_973611.1  E2F transcription factor 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973611.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C5B5, Q9FNY0, Q9FV69, Q9M454, Q9SJ49
      UniProtKB/TrEMBL
      A0A178VZ72, A0A654EZA1, A0A7G2EBM7
      Conserved Domains (2) summary
      cd14660
      Location:246 → 350
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:169 → 232
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    2. NM_129160.4 → NP_565831.3  E2F transcription factor 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565831.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VZ72, A0A654EZA1, A0A7G2EBM6
      Conserved Domains (2) summary
      cd14660
      Location:244 → 348
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:169 → 232
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    3. NM_201881.2 → NP_973610.1  E2F transcription factor 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973610.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654EZA1, F4ILT1
      Conserved Domains (2) summary
      pfam02319
      Location:219 → 278
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam16421
      Location:295 → 378
      E2F_CC-MB; E2F transcription factor CC-MB domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FNY0.1

    Gene LinkOut

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