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    ATE2F2 winged-helix DNA-binding transcription factor family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841202, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ATE2F2
    Official Full Name
    winged-helix DNA-binding transcription factor family protein
    Primary source
    TAIR:AT1G47870
    Locus tag
    AT1G47870
    See related
    Araport:AT1G47870
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA HOMOLOG OF E2F C; ATE2FC; E2FC; E2FC TRANSCRIPTION FACTOR; T2E6.2; T2E6_2; TRANSCRIPTION FACTOR-2 E2F2
    Summary
    Member of the E2F transcription factors, (cell cycle genes), key components of the cyclin D/retinoblastoma/E2F pathway. AtE2Fc is regulated by a balance between gene expression and ubiquitin-proteasome proteolysis. AtE2Fc might play a role in cell division and during the transition from skotomorphogenesis to photomorphogenesis. E2Fc has been shown to interact with DPB in its nonphosphorylated form; when E2Fc is phosphorylated, the formation of the E2Fc/DPB heterodimer is lost.
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    Genomic context

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    See ATE2F2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    13
    Sequence:
    Chromosome: 1; NC_003070.9 (17634697..17637809)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene hexokinase 3 Neighboring gene pseudo Neighboring gene hexokinase Neighboring gene miscRNA Neighboring gene Ribonuclease inhibitor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis E2Fc is required for the DNA damage response under UV-B radiation epistatically over the microRNA396 and independently of E2Fe. Gómez MS, et al. Plant J, 2019 Feb. PMID 30427087
    2. Dissecting regulatory pathways of G1/S control in Arabidopsis: common and distinct targets of CYCD3;1, E2Fa and E2Fc. de Jager SM, et al. Plant Mol Biol, 2009 Nov. PMID 19662336
    3. The E2F transcription factor family regulates CENH3 expression in Arabidopsis thaliana. Heckmann S, et al. Plant J, 2011 Nov. PMID 21771121
    4. Light-dependent regulation of DEL1 is determined by the antagonistic action of E2Fb and E2Fc. Berckmans B, et al. Plant Physiol, 2011 Nov. PMID 21908689, Free PMC Article
    5. The balance between cell division and endoreplication depends on E2FC-DPB, transcription factors regulated by the ubiquitin-SCFSKP2A pathway in Arabidopsis. del Pozo JC, et al. Plant Cell, 2006 Sep. PMID 16920782, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Arabidopsis (Arabidopsis thaliana) DEL1 gene was identified as a transcriptional target of the classical E2Fb and E2Fc transcription factors.
      Title: Light-dependent regulation of DEL1 is determined by the antagonistic action of E2Fb and E2Fc.
    2. E2Fc induction led primarily to gene downregulation, and appears to function outside the CYCD3-RBR pathway, does not have a direct effect on cell cycle genes, and promoter analysis suggests a distinct binding site preference.
      Title: Dissecting regulatory pathways of G1/S control in Arabidopsis: common and distinct targets of CYCD3;1, E2Fa and E2Fc.
    3. The interaction of E2FC with DPB is a key factor in controlling the balance between cell proliferation and the switch to the endocycle program.
      Title: The balance between cell division and endoreplication depends on E2FC-DPB, transcription factors regulated by the ubiquitin-SCFSKP2A pathway in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001198237.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glucosinolate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DRM complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    winged-helix DNA-binding transcription factor family protein
    NP_001185166.1
    • ATE2F2; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Transcription factor E2F/dimerisation partner (TDP) (InterPro:IPR003316), E2F Family (InterPro:IPR015633); BEST Arabidopsis thaliana protein match is: E2F transcription factor 1 (TAIR:AT5G22220.3).
    NP_175222.1
    • ATE2F2; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), Transcription factor E2F/dimerisation partner (TDP) (InterPro:IPR003316), E2F Family (InterPro:IPR015633); BEST Arabidopsis thaliana protein match is: E2F transcription factor 1 (TAIR:AT5G22220.3); Has 948 Blast hits to 896 proteins in 121 species: Archae - 0; Bacteria - 0; Metazoa - 593; Fungi - 12; Plants - 245; Viruses - 0; Other Eukaryotes - 98 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      17634697..17637809
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_103684.3 → NP_175222.1  winged-helix DNA-binding transcription factor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175222.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94LY0, Q9FV70, Q9FZG7
      UniProtKB/TrEMBL
      A0A178WB46, A0A5S9WK18, A0A654ELL0
      Conserved Domains (2) summary
      cd14660
      Location:231 → 336
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:157 → 220
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    2. NM_001198237.1 → NP_001185166.1  winged-helix DNA-binding transcription factor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185166.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W9F7, A0A5S9WK18, A0A654ELL0, F4HV47
      Conserved Domains (2) summary
      cd14660
      Location:230 → 335
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:156 → 219
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FV70.1

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