NSL1 MAC/Perforin domain-containing protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: NSL1
Official Full Name: MAC/Perforin domain-containing protein
Primary source: TAIR:AT1G28380
Locus tag: AT1G28380
See related: Araport:AT1G28380
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F3M18.18; F3M18_18; necrotic spotted lesions 1
Summary: This gene is predicted to encode a protein involved in negatively regulating salicylic acid-related defense responses and cell death programs. nsl1 mutants develop necrotic lesions spontaneously and show other features of a defense response, such as higher levels of SA and disease resistance-related transcripts, in the absence of a biotic stimulus. The NSL1 protein is predicted to have a MACPF domain, found in proteins that form a transmembrane pore in mammalian immune responses. NSL1 transcript levels do not appear to change in response to biotic stresses, but are elevated by cycloheximide in seedlings, and by sodium chloride in roots.
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Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

NSl1 protein activates programmed cell death via tryptophan metabolism in microbe-associated molecular patterns -triggered immunity.
Title: Dysfunction of Arabidopsis MACPF domain protein activates programmed cell death via tryptophan metabolism in MAMP-triggered immunity.

Submit: New GeneRIF Correction

NM_102605.3

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response by callose deposition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant-type hypersensitive response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of salicylic acid mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of salicylic acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to salt stress	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	HDA more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

NP_564307.1

necrotic spotted lesions 1 (NSL1); CONTAINS InterPro DOMAIN/s: Membrane attack complex component/perforin (MACPF) domain (InterPro:IPR020864); BEST Arabidopsis thaliana protein match is: MAC/Perforin domain-containing protein (TAIR:AT4G24290.2); Has 203 Blast hits to 202 proteins in 18 species: Archae - 0; Bacteria - 0; Metazoa - 1; Fungi - 0; Plants - 202; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).