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    ARI12 RING/U-box superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837098, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ARI12
    Official Full Name
    RING/U-box superfamily protein
    Primary source
    TAIR:AT1G05880
    Locus tag
    AT1G05880
    See related
    Araport:AT1G05880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS ARIADNE 12; ARIADNE 12; ATARI12; T20M3.15; T20M3_15
    Summary
    Encodes ARI12 (ARIADNE 12). ARI12 belongs to a family of #AeoRING between RING fingers' (RBR) domain proteins with E3 ligase activity. Expression of ARI12 is induced by UV-B exposure.
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    Genomic context

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    See ARI12 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    13
    Sequence:
    Chromosome: 1; NC_003070.9 (1775643..1778553)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene INO80 complex subunit D-like protein Neighboring gene hypothetical protein (DUF1685) Neighboring gene RING/U-box superfamily protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Induction of ARI12 upon broad band UV-B radiation is suppressed by UVR8 and cryptochromes. Xie L, et al. Plant Signal Behav, 2012 Nov. PMID 22990446, Free PMC Article
    2. UV-B signaling pathways and fluence rate dependent transcriptional regulation of ARIADNE12. Lang-Mladek C, et al. Physiol Plant, 2012 Aug. PMID 22188380
    3. Identification and characterization of the ARIADNE gene family in Arabidopsis. A group of putative E3 ligases. Mladek C, et al. Plant Physiol, 2003 Jan. PMID 12529512, Free PMC Article
    4. UV-B induction of the E3 ligase ARIADNE12 depends on CONSTITUTIVELY PHOTOMORPHOGENIC 1. Xie L, et al. Plant Physiol Biochem, 2015 Aug. PMID 25817546, Free PMC Article
    5. The AP2/ERF transcription factor AtERF73/HRE1 modulates ethylene responses during hypoxia in Arabidopsis. Yang CY, et al. Plant Physiol, 2011 May. PMID 21398256, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. genetic analyses with transgenes expressing a genomic pmARI12:ARI12-GFP construct confirm the epistatic interaction between COP1 and ARI12 in growth responses to high fluence rate UV-B.
      Title: UV-B induction of the E3 ligase ARIADNE12 depends on CONSTITUTIVELY PHOTOMORPHOGENIC 1.
    2. ARI12 is a member of a gene family in Arabidopsis of 16 genes including two pseudogenes and mainly expressed in roots.
      Title: Identification and characterization of the ARIADNE gene family in Arabidopsis. A group of putative E3 ligases.
    3. ARI12 is a functional RING-HECT E3 ubiquitin ligase which is mono-ubiquitinated. ARI12 transcript and protein abundance depends on COP1 in white light, low and high fluence rates of UV-B.
      Title: UV-B induction of the E3 ligase ARIADNE12 depends on CONSTITUTIVELY PHOTOMORPHOGENIC 1.
    4. ARI12 is a downstream target of the UV-B receptor, UVR8, and the transcription factors HY5 and HYH under low fluence rates. Under high fluence rates of broad band UV-B/A ARI12 transcription is suppressed by UVR8 and the blue light/UV-A receptors cryptochromes 1 and 2. ARI12 expression is independent of phototropin 1 and 2 and phytochomes A and B.
      Title: Induction of ARI12 upon broad band UV-B radiation is suppressed by UVR8 and cryptochromes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to UV-B IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    RING/U-box superfamily protein
    NP_001184919.1
    • ARIADNE 12 (ARI12); FUNCTIONS IN: zinc ion binding; INVOLVED IN: biological_process unknown; EXPRESSED IN: stem, root; CONTAINS InterPro DOMAIN/s: Zinc finger, C6HC-type (InterPro:IPR002867); BEST Arabidopsis thaliana protein match is: IBR domain-containing protein (TAIR:AT2G31510.1).
    NP_172079.2
    • ARIADNE 12 (ARI12); FUNCTIONS IN: zinc ion binding, nucleic acid binding; INVOLVED IN: biological_process unknown; EXPRESSED IN: stem, root; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C6HC-type (InterPro:IPR002867), Zinc finger, CCHC-type (InterPro:IPR001878); BEST Arabidopsis thaliana protein match is: IBR domain-containing protein (TAIR:AT2G31510.1); Has 1339 Blast hits to 1333 proteins in 206 species: Archae - 0; Bacteria - 0; Metazoa - 646; Fungi - 141; Plants - 293; Viruses - 0; Other Eukaryotes - 259 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      1775643..1778553
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001331600.1 → NP_001322817.1  RING/U-box superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AVA0, A0A5S9SVB3, A0A654E8K0, A0A7G2DT75

    2. NM_001197990.1 → NP_001184919.1  RING/U-box superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001184919.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56YK5, Q84RQ9, Q9MA38
      UniProtKB/TrEMBL
      A0A5S9SVB3, A0A654E8K0, A0A7G2DT75
      Conserved Domains (3) summary
      smart00647
      Location:193 → 253
      IBR; In Between Ring fingers
      pfam14319
      Location:111 → 139
      Zn_Tnp_IS91; Transposase zinc-binding domain
      cl19760
      Location:266 → 301
      IBR; IBR domain, a half RING-finger domain

    3. NM_100469.2 → NP_172079.2  RING/U-box superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172079.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9SVB3, A0A654E8K0, A0A7G2DT75
      Conserved Domains (2) summary
      pfam14319
      Location:111 → 139
      Zn_Tnp_IS91; Transposase zinc-binding domain
      cl19760
      Location:193 → 246
      IBR; IBR domain, a half RING-finger domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84RQ9.2

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