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    SARD1 Calmodulin binding protein-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843716, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SARD1
    Official Full Name
    Calmodulin binding protein-like protein
    Primary source
    TAIR:AT1G73805
    Locus tag
    AT1G73805
    See related
    Araport:AT1G73805
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    SAR Deficient 1
    Summary
    Encodes SAR Deficient 1 (SARD1), a key regulator for ICS1 (Isochorismate Synthase 1) induction and salicylic acid (SA) synthesis.
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    Genomic context

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    See SARD1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (27744790..27749248, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene coiled-coil protein Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene mitotic-spindle organizing 1B-like protein (DUF3743) Neighboring gene Core-2/I-branching beta-1,6-N-acetylglucosaminyltransferase family protein Neighboring gene Ssu72-like family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drought attenuates plant defence against bacterial pathogens by suppressing the expression of CBP60g/SARD1 during combined stress. Choudhary A, et al. Plant Cell Environ, 2022 Apr. PMID 35102557
    2. Plant E3 ligases SNIPER1 and SNIPER2 broadly regulate the homeostasis of sensor NLR immune receptors. Wu Z, et al. EMBO J, 2020 Aug 3. PMID 32557679, Free PMC Article
    3. Redundant CAMTA Transcription Factors Negatively Regulate the Biosynthesis of Salicylic Acid and N-Hydroxypipecolic Acid by Modulating the Expression of SARD1 and CBP60g. Sun T, et al. Mol Plant, 2020 Jan 6. PMID 31733371
    4. Calcium-dependent protein kinase 5 links calcium signaling with N-hydroxy-l-pipecolic acid- and SARD1-dependent immune memory in systemic acquired resistance. Guerra T, et al. New Phytol, 2020 Jan. PMID 31469917
    5. The plant-specific transcription factors CBP60g and SARD1 are targeted by a Verticillium secretory protein VdSCP41 to modulate immunity. Qin J, et al. Elife, 2018 May 14. PMID 29757140, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drought attenuates plant defence against bacterial pathogens by suppressing the expression of CBP60g/SARD1 during combined stress.
      Title: Drought attenuates plant defence against bacterial pathogens by suppressing the expression of CBP60g/SARD1 during combined stress.
    2. Redundant CAMTA Transcription Factors Negatively Regulate the Biosynthesis of Salicylic Acid and N-Hydroxypipecolic Acid by Modulating the Expression of SARD1 and CBP60g.
      Title: Redundant CAMTA Transcription Factors Negatively Regulate the Biosynthesis of Salicylic Acid and N-Hydroxypipecolic Acid by Modulating the Expression of SARD1 and CBP60g.
    3. Calcium-dependent protein kinase 5 links calcium signaling with N-hydroxy-l-pipecolic acid- and SARD1-dependent immune memory in systemic acquired resistance.
      Title: Calcium-dependent protein kinase 5 links calcium signaling with N-hydroxy-l-pipecolic acid- and SARD1-dependent immune memory in systemic acquired resistance.
    4. WRKY70 repression of SARD1 is important for fitness.
      Title: WRKY70 prevents axenic activation of plant immunity by direct repression of SARD1.
    5. This work uncovers a virulence strategy in which the Verticillium dahliae secretory protein VdSCP41 directly targets plant transcription factors to inhibit immunity, and reveals Arabidopsis CBP60g, SARD1 and cotton CBP60b as crucial components governing Verticillium dahliae resistance.
      Title: The plant-specific transcription factors CBP60g and SARD1 are targeted by a Verticillium secretory protein VdSCP41 to modulate immunity.
    6. SARD1 and CBP60g orchestrate the induction of plant defense regulators in plant immunity.
      Title: ChIP-seq reveals broad roles of SARD1 and CBP60g in regulating plant immunity.
    7. Putative components of the CBP60g SARD1 signalling network have been uncovered by co-expression analysis. In an electrophoretic mobility shift assay CBP60g and SARD1 were shown to bind specifically to a 10mer oligonucleotide with the sequence GAAATTTTGG. [SARD1]
      Title: Co-expression analysis identifies putative targets for CBP60g and SARD1 regulation.
    8. SARD1 plays an important role during the defense response and does not bind calmodulin. [SARD1]
      Title: CBP60g and SARD1 play partially redundant critical roles in salicylic acid signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_106040.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to molecule of bacterial origin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to oomycetes IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of salicylic acid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of salicylic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of systemic acquired resistance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to UV-B IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Calmodulin binding protein-like protein
    NP_565074.2
    • Calmodulin binding protein-like; CONTAINS InterPro DOMAIN/s: Calmodulin binding protein-like (InterPro:IPR012416); BEST Arabidopsis thaliana protein match is: Calmodulin-binding protein (TAIR:AT5G57580.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      27744790..27749248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106040.3 → NP_565074.2  Calmodulin binding protein-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565074.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93Z50, Q9C9T2
      UniProtKB/TrEMBL
      A0A178WFY4, A0A5S9WU42
      Conserved Domains (1) summary
      pfam07887
      Location:90 → 371
      Calmodulin_bind; Calmodulin binding protein-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C9T2.1

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