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    HPR hydroxypyruvate reductase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843129, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HPR
    Official Full Name
    hydroxypyruvate reductase
    Primary source
    TAIR:AT1G68010
    Locus tag
    AT1G68010
    See related
    Araport:AT1G68010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATHPR1; hydroxypyruvate reductase
    Summary
    Encodes hydroxypyruvate reductase.
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    Genomic context

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    See HPR in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    13
    Sequence:
    Chromosome: 1; NC_003070.9 (25493193..25496053)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene phosphatidylinositol synthase 1 Neighboring gene UDP-Glycosyltransferase / trehalose-phosphatase family protein Neighboring gene RING/FYVE/PHD zinc finger superfamily protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Cytosolic Bypass and G6P Shunt in Plants Lacking Peroxisomal Hydroxypyruvate Reductase. Li J, et al. Plant Physiol, 2019 Jun. PMID 30886114, Free PMC Article
    2. Hydroxypyruvate reductase with a carboxy-terminal targeting signal to microbodies is expressed in Arabidopsis. Mano S, et al. Plant Cell Physiol, 1997 Apr. PMID 9177031
    3. Shoot-specific down-regulation of protein farnesyltransferase (alpha-subunit) for yield protection against drought in canola. Wang Y, et al. Mol Plant, 2009 Jan. PMID 19529821, Free PMC Article
    4. Fatty acid beta-oxidation in germinating Arabidopsis seeds is supported by peroxisomal hydroxypyruvate reductase when malate dehydrogenase is absent. Pracharoenwattana I, et al. Plant Mol Biol, 2010 Jan. PMID 19812894
    5. Peroxisomal hydroxypyruvate reductase is not essential for photorespiration in Arabidopsis but its absence causes an increase in the stoichiometry of photorespiratory CO2 release. Cousins AB, et al. Photosynth Res, 2011 Sep. PMID 21567290

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Cytosolic Bypass and G6P Shunt in Plants Lacking Peroxisomal Hydroxypyruvate Reductase.
      Title: A Cytosolic Bypass and G6P Shunt in Plants Lacking Peroxisomal Hydroxypyruvate Reductase.
    2. Elimination of both HPR and PMDH in peroxisomes causes a slight decrease in the rates of photosynthesis under photorespiratory conditions. [HPR1]
      Title: Peroxisomal hydroxypyruvate reductase is not essential for photorespiration in Arabidopsis but its absence causes an increase in the stoichiometry of photorespiratory CO2 release.
    3. The results indicate that HPR can oxidise NADH at sufficient rate in the absence of PMDH to support beta-oxidation and hence seed germination.
      Title: Fatty acid beta-oxidation in germinating Arabidopsis seeds is supported by peroxisomal hydroxypyruvate reductase when malate dehydrogenase is absent.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001198420.1
    NM_001334339.1
    NM_105471.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxypyruvate reductase (NADH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydroxypyruvate reductase (NADH) activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(U) RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in oxidative photosynthetic carbon pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within photorespiration TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in peroxisome HDA PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hydroxypyruvate reductase
    NP_001185349.1
    • hydroxypyruvate reductase (HPR); CONTAINS InterPro DOMAIN/s: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain (InterPro:IPR006139), D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding (InterPro:IPR006140), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: D-3-phosphoglycerate dehydrogenase (TAIR:AT3G19480.1).
    NP_176968.1
    • hydroxypyruvate reductase (HPR); FUNCTIONS IN: glycerate dehydrogenase activity, poly(U) RNA binding; INVOLVED IN: photorespiration; LOCATED IN: apoplast, chloroplast, peroxisome; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain (InterPro:IPR006139), D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding (InterPro:IPR006140), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: D-3-phosphoglycerate dehydrogenase (TAIR:AT3G19480.1); Has 27648 Blast hits to 27644 proteins in 2724 species: Archae - 466; Bacteria - 17022; Metazoa - 727; Fungi - 1147; Plants - 556; Viruses - 5; Other Eukaryotes - 7725 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      25493193..25496053
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105471.4 → NP_176968.1  hydroxypyruvate reductase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176968.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DHJ0, F4HVJ9, O04213, Q9C9W5
      UniProtKB/TrEMBL
      A0A178WM81, A0A5S9WQL9, A0A654ELZ9
      Conserved Domains (1) summary
      PLN02306
      Location:1 → 386
      PLN02306; hydroxypyruvate reductase

    2. NM_001198420.1 → NP_001185349.1  hydroxypyruvate reductase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185349.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WQL9, A0A654ELZ9
      Conserved Domains (2) summary
      PLN02306
      Location:1 → 387
      PLN02306; hydroxypyruvate reductase
      COG1052
      Location:88 → 357
      LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]

    3. NM_001334339.1 → NP_001320607.1  hydroxypyruvate reductase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ANC0, A0A5S9WQL9, A0A654ELZ9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C9W5.1

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