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    RECQ4B RECQ helicase L4B [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842384, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RECQ4B
    Official Full Name
    RECQ helicase L4B
    Primary source
    TAIR:AT1G60930
    Locus tag
    AT1G60930
    See related
    Araport:AT1G60930
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATRECQ4B; RECQ helicase L4B; RECQ HELICASE L4B; RECQL4B; T7P1.7; T7P1_7
    Summary
    AtRECQ4B mutant showed no sensitivity to DNA damaging agents.Involved in homologous recombination.
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    Genomic context

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    See RECQ4B in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    26
    Sequence:
    Chromosome: 1; NC_003070.9 (22430847..22438877, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Rapid alkalinization factor (RALF) family protein Neighboring gene AGAMOUS-like 55 Neighboring gene SNF1-related protein kinase 2.10 Neighboring gene 2Fe-2S ferredoxin-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two closely related RecQ helicases have antagonistic roles in homologous recombination and DNA repair in Arabidopsis thaliana. Hartung F, et al. Proc Natl Acad Sci U S A, 2007 Nov 20. PMID 18000056, Free PMC Article
    2. Multiple mechanisms limit meiotic crossovers: TOP3α and two BLM homologs antagonize crossovers in parallel to FANCM. Séguéla-Arnaud M, et al. Proc Natl Acad Sci U S A, 2015 Apr 14. PMID 25825745, Free PMC Article
    3. Arabidopsis RecQsim, a plant-specific member of the RecQ helicase family, can suppress the MMS hypersensitivity of the yeast sgs1 mutant. Bagherieh-Najjar MB, et al. Plant Mol Biol, 2003 May. PMID 12856935
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_104773.7

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    RECQ helicase L4B
    NP_176289.7
    • RECQ helicase L4B (RECQ4B); FUNCTIONS IN: in 8 functions; INVOLVED IN: DNA recombination; LOCATED IN: intracellular; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 9 growth stages; CONTAINS InterPro DOMAIN/s: DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), RQC domain (InterPro:IPR018982), DNA helicase, ATP-dependent, RecQ type (InterPro:IPR004589), HRDC-like (InterPro:IPR010997), DNA helicase, ATP-dependent, RecQ type, N-terminal (InterPro:IPR018329), DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site (InterPro:IPR002464), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021), Helicase/RNase D C-terminal, HRDC domain (InterPro:IPR002121); BEST Arabidopsis thaliana protein match is: DNA helicase (RECQl4A) (TAIR:AT1G10930.1); Has 28171 Blast hits to 28052 proteins in 2731 species: Archae - 327; Bacteria - 17551; Metazoa - 2839; Fungi - 1949; Plants - 1368; Viruses - 5; Other Eukaryotes - 4132 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      22430847..22438877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_104773.7 → NP_176289.7  RECQ helicase L4B [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_176289.7

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C959, Q9FT70
      UniProtKB/TrEMBL
      A0A654EJT0
      Conserved Domains (6) summary
      PLN03137
      Location:14 → 1150
      PLN03137; ATP-dependent DNA helicase; Q4-like; Provisional
      cd00079
      Location:666 → 792
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam00270
      Location:471 → 641
      DEAD; DEAD/DEAH box helicase
      pfam00570
      Location:1035 → 1101
      HRDC; HRDC domain
      pfam09382
      Location:883 → 994
      RQC; RQC domain
      pfam16124
      Location:797 → 874
      RecQ_Zn_bind; RecQ zinc-binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FT70.1

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