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    RTL2 RNAse THREE-like protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821587, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RTL2
    Official Full Name
    RNAse THREE-like protein 2
    Primary source
    TAIR:AT3G20420
    Locus tag
    AT3G20420
    See related
    Araport:AT3G20420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATRTL2; RNAse THREE-like protein 2; RNASEIII-LIKE 2
    Summary
    double-stranded RNA binding / ribonuclease III. Required for 3' external transcribed spacer (ETS) cleavage of the pre-rRNA in vivo. Localizes in the nucleus and cytoplasm.
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    Genomic context

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    See RTL2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (7119191..7121023, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene F-box associated ubiquitination effector family protein Neighboring gene calmodulin-domain protein kinase 9 Neighboring gene phosphorylated adapter RNA export-like protein Neighboring gene Alpha amylase family protein Neighboring gene B-cell receptor-associated protein 31-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis RNASE THREE LIKE2 Modulates the Expression of Protein-Coding Genes via 24-Nucleotide Small Interfering RNA-Directed DNA Methylation. Elvira-Matelot E, et al. Plant Cell, 2016 Feb. PMID 26764378, Free PMC Article
    2. An Arabidopsis RNase III-like protein, AtRTL2, cleaves double-stranded RNA in vitro. Kiyota E, et al. J Plant Res, 2011 May. PMID 20978817
    3. Characterization of a ribonuclease III-like protein required for cleavage of the pre-rRNA in the 3'ETS in Arabidopsis. Comella P, et al. Nucleic Acids Res, 2008 Mar. PMID 18158302, Free PMC Article
    4. Specific interactions between Dicer-like proteins and HYL1/DRB-family dsRNA-binding proteins in Arabidopsis thaliana. Hiraguri A, et al. Plant Mol Biol, 2005 Jan. PMID 15821876
    5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Changes in 24-nucleotide siRNA levels also affect DNA methylation levels at such loci and inversely correlate with mRNA steady state levels, thus implicating RTL2 in the regulation of protein-coding gene expression.
      Title: Arabidopsis RNASE THREE LIKE2 Modulates the Expression of Protein-Coding Genes via 24-Nucleotide Small Interfering RNA-Directed DNA Methylation.
    2. Arabidopsis thaliana RTL2 increases the amount of small RNA in vivo.
      Title: An Arabidopsis RNase III-like protein, AtRTL2, cleaves double-stranded RNA in vitro.
    3. Results indicate that AtRTL2 may use a dimeric mechanism to cleave double-stranded RNA.
      Title: Characterization of a ribonuclease III-like protein required for cleavage of the pre-rRNA in the 3'ETS in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_112933.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ribonuclease III activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNAse THREE-like protein 2
    NP_566661.1
    • RNAse THREE-like protein 2 (RTL2); FUNCTIONS IN: double-stranded RNA binding, ribonuclease III activity; INVOLVED IN: RNA processing; LOCATED IN: nucleus, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Double-stranded RNA-binding (InterPro:IPR001159), Ribonuclease III (InterPro:IPR000999); BEST Arabidopsis thaliana protein match is: RNAse THREE-like protein 3 (TAIR:AT5G45150.1); Has 7842 Blast hits to 7448 proteins in 2591 species: Archae - 23; Bacteria - 4871; Metazoa - 597; Fungi - 359; Plants - 331; Viruses - 17; Other Eukaryotes - 1644 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      7119191..7121023 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112933.3 → NP_566661.1  RNAse THREE-like protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566661.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94B67, Q9LTQ0
      UniProtKB/TrEMBL
      A0A7G2EM66
      Conserved Domains (4) summary
      COG0571
      Location:54 → 294
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd00048
      Location:313 → 385
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      cd00593
      Location:75 → 226
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      pfam00035
      Location:232 → 292
      dsrm; Double-stranded RNA binding motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LTQ0.1

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