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    mMDH2 Lactate/malate dehydrogenase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820731, updated on 18-Sep-2024

    Summary

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    Official Symbol
    mMDH2
    Official Full Name
    Lactate/malate dehydrogenase family protein
    Primary source
    TAIR:AT3G15020
    Locus tag
    AT3G15020
    See related
    Araport:AT3G15020
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    mitochondrial malate dehydrogenase 2
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    Genomic context

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    See mMDH2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (5055741..5058249)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Class I glutamine amidotransferase-like superfamily protein Neighboring gene cobalt ion binding protein Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene TCP family transcription factor 4 Neighboring gene senescence regulator (Protein of unknown function, DUF584)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Negative regulation of cadmium tolerance in Arabidopsis by MMDH2. Wu X, et al. Plant Mol Biol, 2019 Nov. PMID 31617145
    2. Loss of Mitochondrial Malate Dehydrogenase Activity Alters Seed Metabolism Impairing Seed Maturation and Post-Germination Growth in Arabidopsis. Sew YS, et al. Plant Physiol, 2016 Jun. PMID 27208265, Free PMC Article
    3. Mitochondrial malate dehydrogenase lowers leaf respiration and alters photorespiration and plant growth in Arabidopsis. Tomaz T, et al. Plant Physiol, 2010 Nov. PMID 20876337, Free PMC Article
    4. Plants Possess a Cyclic Mitochondrial Metabolic Pathway similar to the Mammalian Metabolic Repair Mechanism Involving Malate Dehydrogenase and l-2-Hydroxyglutarate Dehydrogenase. Hüdig M, et al. Plant Cell Physiol, 2015 Sep. PMID 26203119
    5. The Extra-Pathway Interactome of the TCA Cycle: Expected and Unexpected Metabolic Interactions. Zhang Y, et al. Plant Physiol, 2018 Jul. PMID 29794018, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that the MMDH2 gene negatively regulates cadmium (Cd) tolerance by modulating reactive oxygen species (ROS) levels and the ROS-mediated signaling, thus, affecting the expression of PDR8.
      Title: Negative regulation of cadmium tolerance in Arabidopsis by MMDH2.
    2. This study has shown that mMDH is an important respiratory element in Arabidopsis seeds, with a significant impact on early seedling growth. Perturbation of both mMDH genes in Arabidopsis seeds significantly elevated respiration rates at all stages of seed maturation, markedly reduced reserve accumulation, and accelerated the aging process in seeds.
      Title: Loss of Mitochondrial Malate Dehydrogenase Activity Alters Seed Metabolism Impairing Seed Maturation and Post-Germination Growth in Arabidopsis.
    3. a metabolic repair cycle involving mMDH and l-2HGDH is conserved in plant and mammalian mitochondria. [Malate dehydrogenase] [mMDH2]
      Title: Plants Possess a Cyclic Mitochondrial Metabolic Pathway similar to the Mammalian Metabolic Repair Mechanism Involving Malate Dehydrogenase and l-2-Hydroxyglutarate Dehydrogenase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001084687.1
    NM_112364.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-malate dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-malate dehydrogenase (NAD+) activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables copper ion binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in malate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    Lactate/malate dehydrogenase family protein
    NP_001078156.1
    • Lactate/malate dehydrogenase family protein; FUNCTIONS IN: malate dehydrogenase activity, copper ion binding; INVOLVED IN: defense response to bacterium; LOCATED IN: mitochondrion, apoplast, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Lactate/malate dehydrogenase, C-terminal (InterPro:IPR022383), Malate dehydrogenase, NAD-dependent, eukaryote/gamma proteobacteria (InterPro:IPR010097), NAD(P)-binding domain (InterPro:IPR016040), L-lactate/malate dehydrogenase (InterPro:IPR001557), Lactate/malate dehydrogenase, N-terminal (InterPro:IPR001236), Malate dehydrogenase, active site (InterPro:IPR001252), Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal (InterPro:IPR015955); BEST Arabidopsis thaliana protein match is: Lactate/malate dehydrogenase family protein (TAIR:AT1G53240.1); Has 16805 Blast hits to 16803 proteins in 5273 species: Archae - 237; Bacteria - 11900; Metazoa - 1175; Fungi - 513; Plants - 469; Viruses - 0; Other Eukaryotes - 2511 (source: NCBI BLink).
    NP_188120.1
    • Lactate/malate dehydrogenase family protein; FUNCTIONS IN: malate dehydrogenase activity, copper ion binding; INVOLVED IN: defense response to bacterium; LOCATED IN: mitochondrion, apoplast, membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Lactate/malate dehydrogenase, N-terminal (InterPro:IPR001236), Lactate/malate dehydrogenase, C-terminal (InterPro:IPR022383), NAD(P)-binding domain (InterPro:IPR016040), Malate dehydrogenase, NAD-dependent, eukaryote/gamma proteobacteria (InterPro:IPR010097), L-lactate/malate dehydrogenase (InterPro:IPR001557), Malate dehydrogenase, active site (InterPro:IPR001252), Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal (InterPro:IPR015955); BEST Arabidopsis thaliana protein match is: Lactate/malate dehydrogenase family protein (TAIR:AT1G53240.1); Has 17183 Blast hits to 17180 proteins in 5309 species: Archae - 237; Bacteria - 12010; Metazoa - 1188; Fungi - 539; Plants - 657; Viruses - 0; Other Eukaryotes - 2552 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      5055741..5058249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112364.4 → NP_188120.1  Lactate/malate dehydrogenase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188120.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LKA3
      UniProtKB/TrEMBL
      A0A178VBJ9, A0A7G2EQA6
      Conserved Domains (1) summary
      PLN00106
      Location:14 → 334
      PLN00106; malate dehydrogenase

    2. NM_001084687.1 → NP_001078156.1  Lactate/malate dehydrogenase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078156.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VBJ9, A8MQK3
      Conserved Domains (2) summary
      cd01337
      Location:31 → 302
      MDH_glyoxysomal_mitochondrial; Glyoxysomal and mitochondrial malate dehydrogenases
      PLN00106
      Location:14 → 302
      PLN00106; malate dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LKA3.1

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