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    Leucine-rich repeat transmembrane protein kinase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820713, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Leucine-rich repeat transmembrane protein kinase
    Primary source
    TAIR:AT3G14840
    Locus tag
    AT3G14840
    See related
    Araport:AT3G14840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    LIK1; LysM RLK1-interacting kinase 1
    Summary
    Encodes LRR-RLK protein that is localized to the plasma membrane and is involved in regulation of plant innate immunity to microbes. LIK1 is phosphorylated by CERK1, a kinase involved in chitin perception.
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    24
    Sequence:
    Chromosome: 3; NC_003074.8 (4988008..4994109)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein Neighboring gene epstein-barr nuclear antigen Neighboring gene TRICHOME BIREFRINGENCE-LIKE 41 Neighboring gene tRNA-Cys

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A brassinosteroid-signaling kinase interacts with multiple receptor-like kinases in Arabidopsis. Xu P, et al. Mol Plant, 2014 Feb. PMID 24051702, Free PMC Article
    2. Tip Growth Defective1 interacts with the cellulose synthase complex to regulate cellulose synthesis in Arabidopsis thaliana. Lampugnani ER, et al. PLoS One, 2024. PMID 38358988, Free PMC Article
    3. LIK1, a CERK1-interacting kinase, regulates plant immune responses in Arabidopsis. Le MH, et al. PLoS One, 2014. PMID 25036661, Free PMC Article
    4. An extracellular network of Arabidopsis leucine-rich repeat receptor kinases. Smakowska-Luzan E, et al. Nature, 2018 Jan 18. PMID 29320478, Free PMC Article
    5. Mapping the Arabidopsis organelle proteome. Dunkley TP, et al. Proc Natl Acad Sci U S A, 2006 Apr 25. PMID 16618929, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LIK1 directly interacts with CERK1 and regulates MAMP-triggered innate immunity. [LIK1]
      Title: LIK1, a CERK1-interacting kinase, regulates plant immune responses in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_112345.7
    NM_112346.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within jasmonic acid and ethylene-dependent systemic resistance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    Leucine-rich repeat transmembrane protein kinase
    NP_188102.5
    • Leucine-rich repeat transmembrane protein kinase; FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Malectin/receptor-like protein kinase (InterPro:IPR021720), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat (InterPro:IPR001611), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Leucine-rich repeat transmembrane protein kinase (TAIR:AT1G53420.1); Has 185540 Blast hits to 134573 proteins in 4786 species: Archae - 122; Bacteria - 17971; Metazoa - 51218; Fungi - 10628; Plants - 83318; Viruses - 446; Other Eukaryotes - 21837 (source: NCBI BLink).
    NP_566494.1
    • Leucine-rich repeat transmembrane protein kinase; FUNCTIONS IN: protein kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; BEST Arabidopsis thaliana protein match is: Leucine-rich repeat transmembrane protein kinase (TAIR:AT1G07650.1); Has 83 Blast hits to 83 proteins in 11 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 83; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      4988008..4994109
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112345.7 → NP_188102.5  Leucine-rich repeat transmembrane protein kinase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188102.5

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0LGN2, Q94EW5, Q9LH71
      UniProtKB/TrEMBL
      A0A178VFX9, A0A654F792
      Conserved Domains (4) summary
      PLN00113
      Location:12 → 944
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      cd14066
      Location:678 → 945
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
      sd00033
      Location:113 → 135
      LRR_RI; leucine-rich repeat [structural motif]
      pfam11721
      Location:403 → 590
      Malectin; Di-glucose binding within endoplasmic reticulum

    2. NM_112346.4 → NP_566494.1  Leucine-rich repeat transmembrane protein kinase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566494.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0LGN2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C0LGN2.1

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