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    FEI1 Leucine-rich repeat protein kinase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 840032, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FEI1
    Official Full Name
    Leucine-rich repeat protein kinase family protein
    Primary source
    TAIR:AT1G31420
    Locus tag
    AT1G31420
    See related
    Araport:AT1G31420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    FEI 1; FEI2; T8E3.2; T8E3_2
    Summary
    Encodes a plasma membrane localized leucine-rich repeat receptor kinase that is involved in cell wall elongation. Loss of function mutations of FEI1 and FEI2 exhibit defects in root and hypocotyl cell elongation. Double mutants are defective in cell wall biosynthesis and have thick hypocotyls, and short, thick roots.
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    Genomic context

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    See FEI1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    14
    Sequence:
    Chromosome: 1; NC_003070.9 (11249600..11253915)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene TRAF-like family protein Neighboring gene putrescine-binding periplasmic protein-like protein Neighboring gene Pentatricopeptide repeat (PPR-like) superfamily protein Neighboring gene SH3 domain-containing protein Neighboring gene Eukaryotic aspartyl protease family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Defects in the cell wall and its deposition caused by loss-of-function of three RLKs alter root hydrotropism in Arabidopsis thaliana. Chang J, et al. Nat Commun, 2024 Mar 26. PMID 38531848, Free PMC Article
    2. Glycosylation of a Fasciclin-Like Arabinogalactan-Protein (SOS5) Mediates Root Growth and Seed Mucilage Adherence via a Cell Wall Receptor-Like Kinase (FEI1/FEI2) Pathway in Arabidopsis. Basu D, et al. PLoS One, 2016. PMID 26731606, Free PMC Article
    3. Two leucine-rich repeat receptor kinases mediate signaling, linking cell wall biosynthesis and ACC synthase in Arabidopsis. Xu SL, et al. Plant Cell, 2008 Nov. PMID 19017745, Free PMC Article
    4. A membrane protein/signaling protein interaction network for Arabidopsis version AMPv2. Lalonde S, et al. Front Physiol, 2010. PMID 21423366, Free PMC Article
    5. An extracellular network of Arabidopsis leucine-rich repeat receptor kinases. Smakowska-Luzan E, et al. Nature, 2018 Jan 18. PMID 29320478, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that Arabidopsis proteins GALT2, GALT5, SOS5, FEI1 and FEI2 act in a single genetic signaling pathway.
      Title: Glycosylation of a Fasciclin-Like Arabinogalactan-Protein (SOS5) Mediates Root Growth and Seed Mucilage Adherence via a Cell Wall Receptor-Like Kinase (FEI1/FEI2) Pathway in Arabidopsis.
    2. The protein kinases FEI1 and FEI2 help regulate cell expansion and cell wall biosynthesis through interaction with ACC synthase. [FEI1]
      Title: Two leucine-rich repeat receptor kinases mediate signaling, linking cell wall biosynthesis and ACC synthase in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001198193.1
    NM_001332962.1
    NM_102881.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within unidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Leucine-rich repeat protein kinase family protein
    NP_001185122.1
    • FEI 1 (FEI1); FUNCTIONS IN: protein serine/threonine kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation, transmembrane receptor protein tyrosine kinase signaling pathway, plant-type cell wall organization, unidimensional cell growth; LOCATED IN: endomembrane system; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Leucine-rich repeat protein kinase family protein (TAIR:AT2G35620.2).
    NP_174427.3
    • FEI 1 (FEI1); FUNCTIONS IN: protein serine/threonine kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation, transmembrane receptor protein tyrosine kinase signaling pathway, plant-type cell wall organization, unidimensional cell growth; LOCATED IN: endomembrane system; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Leucine-rich repeat (InterPro:IPR001611), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: Leucine-rich repeat protein kinase family protein (TAIR:AT2G35620.2); Has 175765 Blast hits to 127689 proteins in 4472 species: Archae - 166; Bacteria - 15621; Metazoa - 46011; Fungi - 10289; Plants - 82046; Viruses - 467; Other Eukaryotes - 21165 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      11249600..11253915
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198193.1 → NP_001185122.1  Leucine-rich repeat protein kinase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185122.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0LGF4, Q9C867
      UniProtKB/TrEMBL
      A0A178WQE9
      Conserved Domains (4) summary
      sd00033
      Location:78 → 99
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00069
      Location:306 → 571
      Pkinase; Protein kinase domain
      pfam08263
      Location:30 → 70
      LRRNT_2; Leucine rich repeat N-terminal domain
      cl21453
      Location:312 → 574
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001332962.1 → NP_001320669.1  Leucine-rich repeat protein kinase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WRG6, F4I9D5

    3. NM_102881.4 → NP_174427.3  Leucine-rich repeat protein kinase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174427.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178WRG6, F4I9D5
      Conserved Domains (4) summary
      smart00221
      Location:306 → 574
      STYKc; Protein kinase; unclassified specificity
      sd00033
      Location:78 → 99
      LRR_RI; leucine-rich repeat [structural motif]
      pfam08263
      Location:30 → 70
      LRRNT_2; Leucine rich repeat N-terminal domain
      cl21453
      Location:312 → 575
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C0LGF4.1

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