STOMAGEN stomagen [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: STOMAGEN
Official Full Name: stomagen
Primary source: TAIR:AT4G12970
Locus tag: AT4G12970
See related: Araport:AT4G12970
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: EPFL9; F25G13.60; F25G13_60
Summary: Encodes a cysteine-rich peptide, a secretory factor that is produced in the mesophyll cells and acts on the epidermis to increase stomatal formation. Its mature form is a 45-aa peptide with three intramolecular disulfide bonds. It is proposed that STOMAGEN increases stomatal number by competing with two negative regulators of stomatal density, EPF1 and EPF2, possibly through direct interaction with the receptor-like protein TMM. Its transcript levels change after inducing MUTE expression in a mute background.
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Genomic context

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See STOMAGEN in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 3

Sequence:: Chromosome: 4; NC_003075.7 (7585869..7587099, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Peptide Pair Coordinates Regular Ovule Initiation Patterns with Seed Number and Fruit Size.
Title: A Peptide Pair Coordinates Regular Ovule Initiation Patterns with Seed Number and Fruit Size.
Our analysis shows that HY5 does have the potential to regulate the STOM promoter in vitro and that HY5 is expressed in both the epidermis and mesophyll. However, analysis of hy5 and hy5 hyh double mutants (HYH; HY5-HOMOLOG), found that they had normal stomatal development under different light conditions and the expression of stomatal developmental genes was not perturbed following light shift experiments.
Title: HY5 is not integral to light mediated stomatal development in Arabidopsis.
Analysis of gain and loss of function of STOMAGEN detailed its function as a positive regulator of stomatal formation on both sides of the leaf, not only in terms of stomatal density across the leaf surface but also in terms of their stomatal index.
Title: Light-induced STOMAGEN-mediated stomatal development in Arabidopsis leaves.
mutation in the leucine-rich receptor kinase ERECTA and its putative peptide ligand STOMAGEN block the effect of hydrogen peroxide on root cortex proliferation
Title: SPINDLY, ERECTA, and its ligand STOMAGEN have a role in redox-mediated cortex proliferation in the Arabidopsis root.
Stomagen (also called EPF-LIKE9) peptide, which promotes stomatal development, requires ERECTA (ER)-family receptor kinases and interferes with the inhibition of stomatal development by the EPIDERMAL PATTERNING FACTOR 2 (EPF2)-ER module
Title: Competitive binding of antagonistic peptides fine-tunes stomatal patterning.
EPF1/EPF2-like proteins form an additional disulfide bond in their loop regions and show greater flexibility in these regions than EPFL9/Stomagen-like peptides.
Title: Evolutionary relationship and structural characterization of the EPF/EPFL gene family.
MONOPTEROS directly binds to the STOMAGEN promoter to suppress its expression in mesophyll and inhibit stomatal development.
Title: Auxin inhibits stomatal development through MONOPTEROS repression of a mobile peptide gene STOMAGEN in mesophyll.
control of stomatal density by the STOMAGEN gene
Title: Enhancement of leaf photosynthetic capacity through increased stomatal density in Arabidopsis.
This study provides evidence of a mesophyll-derived positive regulator of stomatal development, called stomagen. [stomagen]
Title: Stomagen positively regulates stomatal density in Arabidopsis.
We propose that stomagen is a mesophyll-to-epidermis signaling molecule that positively regulates stomatal density. [STOMAGEN]
Title: Stomatal density is controlled by a mesophyll-derived signaling molecule.

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General gene information

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NM_117366.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor serine/threonine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell-cell signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in guard cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of stomatal complex development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of stomatal complex development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stomatal complex development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within stomatal complex patterning	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within stomatal complex patterning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: stomagen

NP_193033.1

STOMAGEN (STOMAGEN); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: stomatal complex patterning, regulation of stomatal complex development, positive regulation of stomatal complex development, cell-cell signaling; LOCATED IN: endomembrane system; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 12 growth stages; Has 29 Blast hits to 29 proteins in 10 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 29; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).