AFB4 RNI-like superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: AFB4
Official Full Name: RNI-like superfamily protein
Primary source: TAIR:AT4G24390
Locus tag: AT4G24390
See related: Araport:AT4G24390
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: auxin signaling F-box 4; T22A6.220; T22A6_220
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Genomic context

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See AFB4 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 4

Sequence:: Chromosome: 4; NC_003075.7 (12613076..12616238, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Exogenous Auxin Induces Transverse Microtubule Arrays Through TRANSPORT INHIBITOR RESPONSE1/AUXIN SIGNALING F-BOX Receptors.
Title: Exogenous Auxin Induces Transverse Microtubule Arrays Through TRANSPORT INHIBITOR RESPONSE1/AUXIN SIGNALING F-BOX Receptors.
Phenotypes similar to rms2 were found in Arabidopsis afb4/5 mutants, including increased shoot branching, low expression of SL biosynthesis genes and high auxin levels in stems
Title: The pea branching RMS2 gene encodes the PsAFB4/5 auxin receptor and is involved in an auxin-strigolactone regulation loop.
This effect of elevated auxin levels requires the activity of SKP-Cullin-F-box(TIR1/AFB) (SCF(TIR1/AFB))-dependent pathway. Importantly, also suboptimal auxin levels mediate PIN degradation utilizing the same signalling pathway.
Title: SCF(TIR1/AFB)-auxin signalling regulates PIN vacuolar trafficking and auxin fluxes during root gravitropism.
Complete loss-of-function of the AFB4 gene confers defects in many aspects of the plant life cycle including lateral root development, hypocotyl elongation, to specific phytopathogens
Title: F-box protein AFB4 plays a crucial role in plant growth, development and innate immunity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_118572.3

Supported by ESTs:

NM_202878.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables auxin binding	ISS Inferred from Sequence or Structural Similarity more info
enables auxin receptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables inositol hexakisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in auxin-activated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in response to auxin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IPI Inferred from Physical Interaction more info	PubMed
part_of SCF ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: RNI-like superfamily protein

NP_567702.2

RNI-like superfamily protein; BEST Arabidopsis thaliana protein match is: auxin F-box protein 5 (TAIR:AT5G49980.1); Has 1708 Blast hits to 1373 proteins in 117 species: Archae - 0; Bacteria - 2; Metazoa - 531; Fungi - 30; Plants - 1073; Viruses - 0; Other Eukaryotes - 72 (source: NCBI BLink).

NP_974607.1

RNI-like superfamily protein; BEST Arabidopsis thaliana protein match is: auxin F-box protein 5 (TAIR:AT5G49980.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

12613076..12616238 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_118572.3 → NP_567702.2 RNI-like superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_567702.2

Status: REVIEWED

UniProtKB/Swiss-Prot

B9DFR4, Q8RWQ8, Q9STV5

UniProtKB/TrEMBL

A0A654FSF1, A0A7G2F239

Conserved Domains (4) summary

cd09293
Location:384 → 538

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:338 → 362

LRR_AMN1; leucine-rich repeat [structural motif]

pfam18511
Location:51 → 90

F-box_5

pfam18791
Location:112 → 157

Transp_inhibit; Transport inhibitor response 1 protein domain
NM_202878.2 → NP_974607.1 RNI-like superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974607.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B9DFR4, Q8RWQ8, Q9STV5

UniProtKB/TrEMBL

A0A654FSF1, A0A7G2F239

Conserved Domains (4) summary

cd09293
Location:384 → 538

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:338 → 362

LRR_AMN1; leucine-rich repeat [structural motif]

pfam18511
Location:51 → 90

F-box_5

pfam18791
Location:112 → 157

Transp_inhibit; Transport inhibitor response 1 protein domain