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    Leucine-rich repeat transmembrane protein kinase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828983, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Leucine-rich repeat transmembrane protein kinase family protein
    Primary source
    TAIR:AT4G28650
    Locus tag
    AT4G28650
    See related
    Araport:AT4G28650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    PXL2; PXY-like2; T5F17.100; T5F17_100
    Summary
    Encodes one of the two putative eLRR kinase closely related to PXY (At1g08590/PXL1 and At4g28650/PXL2). Insertion mutants in either pxl1 or pxl2 do not exhibit an obvious phenotype in the stem; double-mutant combinations of a Col allele, of pxy (pxy-3) with pxl1 and pxl2, generate a more severe vascular phenotype than pxy-3 alone, suggesting that these genes act synergistically with PXY in regulating vascular-tissue development in the stem.
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    2
    Sequence:
    Chromosome: 4; NC_003075.7 (14143958..14147537, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ABC transporter of the mitochondrion 2 Neighboring gene ABC transporter of the mitochondrion 1 Neighboring gene indole-3-acetic acid inducible 11 Neighboring gene ncRNA Neighboring gene photosystem II reaction center PSB28 protein Neighboring gene cysteine-rich RECEPTOR-like kinase, putative (DUF26)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression, purification, and phylogenetic analysis of MDIS1-INTERACTING RECEPTOR-LIKE KINASE1 (MIK1). Trihemasava K, et al. Protein J, 2020 Oct. PMID 33104960, Free PMC Article
    2. CEPR2 phosphorylates and accelerates the degradation of PYR/PYLs in Arabidopsis. Yu Z, et al. J Exp Bot, 2019 Oct 15. PMID 31232446, Free PMC Article
    3. CLE42 binding induces PXL2 interaction with SERK2. Mou S, et al. Protein Cell, 2017 Aug. PMID 28677102, Free PMC Article
    4. PXY, a receptor-like kinase essential for maintaining polarity during plant vascular-tissue development. Fisher K, et al. Curr Biol, 2007 Jun 19. PMID 17570668
    5. A receptor heteromer mediates the male perception of female attractants in plants. Wang T, et al. Nature, 2016 Mar 10. PMID 26863186

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. It is hypothesized that MIK1 can also interact with CLE peptides and use the SERK family of proteins as a co-receptor for signal propagation. [MIK1].
      Title: Expression, purification, and phylogenetic analysis of MDIS1-INTERACTING RECEPTOR-LIKE KINASE1 (MIK1).
    2. Loss of function by T-DNA insertion in C-terminally encoded peptide receptor 2 (CEPR2) together with phloem intercalated with xylem (PXY) and PXY-Like 2 (PXL2) led to abscisic acid (ABA) hypersensitivity, while CEPR2 overexpression led to ABA insensitivity compared with the wild type, indicating the redundant and negative roles of CEPR2, PXY, and PXL2 in ABA signaling.
      Title: CEPR2 phosphorylates and accelerates the degradation of PYR/PYLs in Arabidopsis.
    3. CLE42 binding induces PXL2 interaction with SERK2.
      Title: CLE42 binding induces PXL2 interaction with SERK2.
    4. MDIS1-MIK is a cell-surface receptor heteromer on the pollen tube that perceives female attractant LURE1 in A. thaliana. LURE1 specifically binds the extracellular domains of MDIS1, MIK1 and MIK2, whereas mdis1 and mik1 mik2 mutant pollen tubes respond less sensitively to LURE1. [MIK1]
      Title: A receptor heteromer mediates the male perception of female attractants in plants.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_119007.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phloem or xylem histogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen tube guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in procambium histogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in pollen tube IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Leucine-rich repeat transmembrane protein kinase family protein
    NP_194594.1
    • Leucine-rich repeat transmembrane protein kinase family protein; FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, ATP binding; INVOLVED IN: transmembrane receptor protein tyrosine kinase signaling pathway, protein amino acid phosphorylation; LOCATED IN: endomembrane system; EXPRESSED IN: hypocotyl, root, guard cell; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Leucine-rich receptor-like protein kinase family protein (TAIR:AT1G08590.1); Has 236312 Blast hits to 142770 proteins in 4269 species: Archae - 150; Bacteria - 21752; Metazoa - 75925; Fungi - 11533; Plants - 97988; Viruses - 432; Other Eukaryotes - 28532 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      14143958..14147537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119007.3 → NP_194594.1  Leucine-rich repeat transmembrane protein kinase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194594.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M0G7
      UniProtKB/TrEMBL
      A0A178V5Y0, A0A5S9XYX1
      Conserved Domains (2) summary
      PLN00113
      Location:27 → 986
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:334 → 354
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M0G7.1

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