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    CLC-E chloride channel E [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829696, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CLC-E
    Official Full Name
    chloride channel E
    Primary source
    TAIR:AT4G35440
    Locus tag
    AT4G35440
    See related
    Araport:AT4G35440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCLC-E; chloride channel E; CHLORIDE CHANNEL E; CLCE; F15J1.10; F15J1_10
    Summary
    Enclodes a choride channel protein that is localized to the thlakoid membrane.
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    Genomic context

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    See CLC-E in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    7
    Sequence:
    Chromosome: 4; NC_003075.7 (16835986..16839375, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Clathrin adaptor complex small chain family protein Neighboring gene dihydroflavonol 4-reductase-like1 Neighboring gene uncharacterized protein Neighboring gene ankyrin repeat-containing protein 2 Neighboring gene NADPH-dependent thioredoxin reductase B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis Thylakoid Chloride Channel AtCLCe Functions in Chloride Homeostasis and Regulation of Photosynthetic Electron Transport. Herdean A, et al. Front Plant Sci, 2016. PMID 26904077, Free PMC Article
    2. Two anion transporters AtClCa and AtClCe fulfil interconnecting but not redundant roles in nitrate assimilation pathways. Monachello D, et al. New Phytol, 2009. PMID 19402883
    3. Two members of the Arabidopsis CLC (chloride channel) family, AtCLCe and AtCLCf, are associated with thylakoid and Golgi membranes, respectively. Marmagne A, et al. J Exp Bot, 2007. PMID 17872921
    4. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001203995.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables voltage-gated chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of photosynthesis, light reaction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within thylakoid membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast thylakoid membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chloride channel E
    NP_001190924.1
    • chloride channel E (CLC-E); FUNCTIONS IN: ion channel activity, voltage-gated chloride channel activity; INVOLVED IN: chloride transport, transmembrane transport; LOCATED IN: chloroplast thylakoid membrane, membrane; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Chloride channel, core (InterPro:IPR014743), Chloride channel, voltage gated (InterPro:IPR001807), Cystathionine beta-synthase, core (InterPro:IPR000644); BEST Arabidopsis thaliana protein match is: chloride channel F (TAIR:AT1G55620.2).
    NP_567985.1
    • chloride channel E (CLC-E); FUNCTIONS IN: ion channel activity, voltage-gated chloride channel activity; INVOLVED IN: chloride transport, transmembrane transport; LOCATED IN: chloroplast thylakoid membrane, membrane; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Chloride channel, core (InterPro:IPR014743), Chloride channel, voltage gated (InterPro:IPR001807), Cystathionine beta-synthase, core (InterPro:IPR000644); BEST Arabidopsis thaliana protein match is: chloride channel F (TAIR:AT1G55620.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16835986..16839375 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119709.1 → NP_567985.1  chloride channel E [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567985.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65486, Q8GX93, Q93XN4, Q9SVX1
      UniProtKB/TrEMBL
      A0A178UW87
      Conserved Domains (4) summary
      COG0517
      Location:561 → 691
      CBS; CBS domain [Signal transduction mechanisms]
      cd00400
      Location:84 → 494
      Voltage_gated_ClC; CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This ...
      cd04592
      Location:567 → 689
      CBS_pair_EriC_assoc_euk; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes. These ion channels are proteins with a seemingly simple task of allowing the passive flow of chloride ions ...
      pfam00654
      Location:135 → 498
      Voltage_CLC; Voltage gated chloride channel

    2. NM_001203995.1 → NP_001190924.1  chloride channel E [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190924.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XZQ3, A0A654FVQ9, F4JN11
      Conserved Domains (2) summary
      cd00400
      Location:84 → 494
      Voltage_gated_ClC; CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This ...
      cd04592
      Location:565 → 692
      CBS_pair_voltage-gated_CLC_euk_bac; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GX93.2

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