PHS2 alpha-glucan phosphorylase 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PHS2
Official Full Name: alpha-glucan phosphorylase 2
Primary source: TAIR:AT3G46970
Locus tag: AT3G46970
See related: Araport:AT3G46970
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: alpha-glucan phosphorylase 2; ALPHA-GLUCAN PHOSPHORYLASE 2; Arabidopsis thaliana alpha-glucan phosphorylase 2; ATPHS2
Summary: Encodes a cytosolic alpha-glucan phosphorylase. In vitro, the enzyme has a preference for branched polysaccharides, such as glycogen.
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Genomic context

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See PHS2 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 16

Sequence:: Chromosome: 3; NC_003074.8 (17301394..17306633, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PHS2 activity is important in the adult stage during low-light conditions and senescence, as well as during prolonged seedling development when carbohydrate levels are unbalanced.
Title: Arabidopsis cytosolic alpha-glycan phosphorylase, PHS2, is important during carbohydrate imbalanced conditions.
A comparison of ATPHS2 and DPE2 from A. thaliana with MalP and MalQ from E. coli is presented.
Title: The role of cytosolic alpha-glucan phosphorylase in maltose metabolism and the comparison of amylomaltase in Arabidopsis and Escherichia coli.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_114564.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables 1,4-alpha-oligoglucan phosphorylase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1,4-alpha-oligoglucan phosphorylase activity	IEA Inferred from Electronic Annotation more info
enables glycogen phosphorylase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to water deprivation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: alpha-glucan phosphorylase 2

NP_190281.1

alpha-glucan phosphorylase 2 (PHS2); FUNCTIONS IN: phosphorylase activity, transferase activity, transferring glycosyl groups; INVOLVED IN: response to cadmium ion, response to water deprivation; LOCATED IN: cytosol, chloroplast; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glycosyl transferase, family 35 (InterPro:IPR000811), Glycogen/starch/alpha-glucan phosphorylase (InterPro:IPR011833); BEST Arabidopsis thaliana protein match is: Glycosyl transferase, family 35 (TAIR:AT3G29320.1); Has 5792 Blast hits to 5741 proteins in 1741 species: Archae - 74; Bacteria - 3953; Metazoa - 555; Fungi - 138; Plants - 232; Viruses - 2; Other Eukaryotes - 838 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

17301394..17306633 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_114564.3 → NP_190281.1 alpha-glucan phosphorylase 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_190281.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q93ZL3, Q9SD76

UniProtKB/TrEMBL

A0A178VC18, W8PUR4

Conserved Domains (2) summary

cd04300
Location:33 → 835

GT1_Glycogen_Phosphorylase; This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of ...

TIGR02093
Location:34 → 835

P_ylase; glycogen/starch/alpha-glucan phosphorylases