U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MKP1 mitogen-activated protein kinase phosphatase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824693, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    MKP1
    Official Full Name
    mitogen-activated protein kinase phosphatase 1
    Primary source
    TAIR:AT3G55270
    Locus tag
    AT3G55270
    See related
    Araport:AT3G55270
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASE 1; ATMKP1; mitogen-activated protein kinase phosphatase 1
    Summary
    Encodes MAP kinase phosphatase 1 (MKP1). Loss of MKP1 results in hypersensitivity to acute UV-B stress, but without impairing UV-B acclimation.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MKP1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (20496081..20500019)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene beta-hexosaminidase 1 Neighboring gene ribosomal protein L23AB Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Regulation of MAPK phosphatase 1 (AtMKP1) by calmodulin in Arabidopsis. Lee K, et al. J Biol Chem, 2008 Aug 29. PMID 18579522, Free PMC Article
    2. MKP1 acts as a key modulator of stomatal development. Jangra R, et al. Plant Signal Behav, 2019. PMID 30983545, Free PMC Article
    3. Mitogen-Activated Protein Kinase Phosphatase 1 (MKP1) Negatively Regulates the Production of Reactive Oxygen Species During Arabidopsis Immune Responses. Escudero V, et al. Mol Plant Microbe Interact, 2019 Apr. PMID 30387369
    4. MAP KINASE PHOSPHATASE1 Controls Cell Fate Transition during Stomatal Development. Tamnanloo F, et al. Plant Physiol, 2018 Sep. PMID 30002258, Free PMC Article
    5. Phosphorylation of Arabidopsis MAP Kinase Phosphatase 1 (MKP1) Is Required for PAMP Responses and Resistance against Bacteria. Jiang L, et al. Plant Physiol, 2017 Dec. PMID 29070514, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dual control of MAPK activities by AP2C1 and MKP1 MAPK phosphatases regulates defence responses in Arabidopsis.
      Title: Dual control of MAPK activities by AP2C1 and MKP1 MAPK phosphatases regulates defence responses in Arabidopsis.
    2. An MKP-MAPK protein phosphorylation cascade controls vascular immunity in plants.
      Title: An MKP-MAPK protein phosphorylation cascade controls vascular immunity in plants.
    3. MKP1 plays an important role at the early stage of stomatal development for the cell fate transition leading to stomatal differentiation.
      Title: MKP1 acts as a key modulator of stomatal development.
    4. MKP1 functions downstream of the heterotrimeric G protein during MAMP-triggered immunity, directly regulating the activity of RBOHD and ROS production as well as other immune responses.
      Title: Mitogen-Activated Protein Kinase Phosphatase 1 (MKP1) Negatively Regulates the Production of Reactive Oxygen Species During Arabidopsis Immune Responses.
    5. Data indicate the important role of MAP KINASE PHOSPHATASE1 (MKP1) in controlling MAPK signaling specificity and cell fate decision during stomatal development.
      Title: MAP KINASE PHOSPHATASE1 Controls Cell Fate Transition during Stomatal Development.
    6. These results provide insight into the roles of phosphorylation in the regulation of MKP1 during pathogen-associated molecular pattern signaling and resistance to bacteria.
      Title: Phosphorylation of Arabidopsis MAP Kinase Phosphatase 1 (MKP1) Is Required for PAMP Responses and Resistance against Bacteria.
    7. These data highlight MPK6 and MKP1 as components of an L-Glutamate pathway linking the auxin response, and cell division for primary root growth.
      Title: Mitogen activated protein kinase 6 and MAP kinase phosphatase 1 are involved in the response of Arabidopsis roots to L-glutamate.
    8. MKP1 role in ultraviolet induced stomatal closure
      Title: Mitogen-Activated Protein Kinase Phosphatases Affect UV-B-Induced Stomatal Closure via Controlling NO in Guard Cells.
    9. This study pinpoints the specificity of MAPK regulation by the different MAPK phosphatases AP2C1 and MKP1, which control the same MAPK substrates, nevertheless leading to different downstream events.
      Title: Protein phosphatase AP2C1 negatively regulates basal resistance and defense responses to Pseudomonas syringae.
    10. These results identify MKP1 as a protein dually targeted to cytosol and peroxisomes.
      Title: MAP kinase phosphatase 1 harbors a novel PTS1 and is targeted to peroxisomes following stress treatments.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_115385.7

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables MAP kinase tyrosine/serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables MAP kinase tyrosine/serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to L-glutamate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to UV-B IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to UV-C IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    mitogen-activated protein kinase phosphatase 1
    NP_567018.5
    • mitogen-activated protein kinase phosphatase 1 (MKP1); CONTAINS InterPro DOMAIN/s: Protein-tyrosine phosphatase, active site (InterPro:IPR016130), Dual-specific/protein-tyrosine phosphatase, conserved region (InterPro:IPR000387), Dual specificity phosphatase, catalytic domain (InterPro:IPR000340), Dual specificity phosphatase, subgroup, catalytic domain (InterPro:IPR020422); BEST Arabidopsis thaliana protein match is: MAPK phosphatase 2 (TAIR:AT3G06110.3); Has 4115 Blast hits to 4050 proteins in 297 species: Archae - 2; Bacteria - 48; Metazoa - 2335; Fungi - 439; Plants - 312; Viruses - 98; Other Eukaryotes - 881 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20496081..20500019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115385.7 → NP_567018.5  mitogen-activated protein kinase phosphatase 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q940K2, Q9C5S1, Q9M3C4
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools