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    RIC4 ROP-interactive CRIB motif-containing protein 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831510, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RIC4
    Official Full Name
    ROP-interactive CRIB motif-containing protein 4
    Primary source
    TAIR:AT5G16490
    Locus tag
    AT5G16490
    See related
    Araport:AT5G16490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MQK4.23; MQK4_23; ROP-interactive CRIB motif-containing protein 4
    Summary
    encodes a member of a novel protein family that contains contain a CRIB (for Cdc42/Rac-interactive binding) motif required for their specific interaction with GTP-bound Rop1 (plant-specific Rho GTPase). It interacts with Rop1 and is involved in pollen tube growth and function, and exocytosis in the pollen tube tip. Protein most similar to RIC2 (family subgroup V). Gene is expressed in all tissues examined.Interacts with ROP2 during pavement cell morphogenesis and with ROP1 to promote apical F-actin assembly.
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    Genomic context

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    See RIC4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (5384250..5385230, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Phosphotyrosine protein phosphatases superfamily protein Neighboring gene RNA-directed DNA polymerase (reverse transcriptase)-related family protein Neighboring gene Protein kinase superfamily protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Rho family GTPase controls actin dynamics and tip growth via two counteracting downstream pathways in pollen tubes. Gu Y, et al. J Cell Biol, 2005 Apr 11. PMID 15824136, Free PMC Article
    2. Arabidopsis interdigitating cell growth requires two antagonistic pathways with opposing action on cell morphogenesis. Fu Y, et al. Cell, 2005 Mar 11. PMID 15766531
    3. Rho-GTPase-dependent filamentous actin dynamics coordinate vesicle targeting and exocytosis during tip growth. Lee YJ, et al. J Cell Biol, 2008 Jun 30. PMID 18591430, Free PMC Article
    4. A genome-wide analysis of Arabidopsis Rop-interactive CRIB motif-containing proteins that act as Rop GTPase targets. Wu G, et al. Plant Cell, 2001 Dec. PMID 11752391, Free PMC Article
    5. An integrative approach to the identification of Arabidopsis and rice genes involved in xylan and secondary wall development. Oikawa A, et al. PLoS One, 2010 Nov 23. PMID 21124849, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_121654.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellulose microfibril organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of vesicle localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen tube growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ROP-interactive CRIB motif-containing protein 4
    NP_197153.1
    • ROP-interactive CRIB motif-containing protein 4 (RIC4); CONTAINS InterPro DOMAIN/s: PAK-box/P21-Rho-binding (InterPro:IPR000095); BEST Arabidopsis thaliana protein match is: ROP-interactive CRIB motif-containing protein 10 (TAIR:AT4G04900.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      5384250..5385230 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121654.3 → NP_197153.1  ROP-interactive CRIB motif-containing protein 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197153.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FFD5
      UniProtKB/TrEMBL
      A0A178UTG6, A0A5S9Y4P0
      Conserved Domains (1) summary
      cd00132
      Location:97 → 133
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FFD5.1

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